35 Results for "

export

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "export" in MCE Product Catalog:

41
Artesunate
Artesunate
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41 Publications Verification
Referencia número: HY-N0193
No. CAS: 88495-63-0
Category:  

Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer

Target:  

STAT Ferroptosis Parasite Virus Protease

Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
32
SC75741
SC75741
0 Images
32 Cited Publications
Referencia número: HY-10496
No. CAS: 913822-46-5
Pureza:  99.24%
Target:  

NF-κB Influenza Virus

Áreas de investigación:  

Infection Cancer

SC75741 is a broad and efficient NF-κB inhibitor with an IC50 of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .
24
Leptomycin B
Leptomycin B
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24 Cited Publications
Referencia número: HY-16909
No. CAS: 87081-35-4
Synonyms: CI 940; LMB
Target:  

CRM1 Fungal Antibiotic

Áreas de investigación:  

Infection Cancer

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .
8
VB124
VB124
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8 Cited Publications
Referencia número: HY-139665
No. CAS: 2230186-18-0
Pureza:  98.91%
Target:  

Monocarboxylate Transporter

Áreas de investigación:  

Cardiovascular Disease

VB124 is an orally active, potent, and selective MCT4 inhibitor. VB124 can specifically inhibit lactate efflux with IC50s of 8.6 nM and 19 nM for lactate import and export in MDA-MB-231 cells, respectively. VB124 is highly selective for MCT4 over MCT1. VB124 can be used for the research of cardiac hypertrophy, heart failure, and metabolism .
3
Eltanexor
Eltanexor
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3 Cited Publications
Referencia número: HY-100423
No. CAS: 1642300-52-4
Pureza:  99.79%
Synonyms: KPT-8602
Target:  

CRM1

Áreas de investigación:  

Cancer

Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines .
2
Verdinexor
Verdinexor
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2 Cited Publications
Referencia número: HY-15970
No. CAS: 1392136-43-4
Synonyms: KPT-335
Target:  

CRM1 Apoptosis RSV

Áreas de investigación:  

Infection Inflammation/Immunology Cancer

Verdinexor (KPT-335) is an orally active inhibitor for selective inhibitor of nuclear export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC50 of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency .
1
GNF4877
GNF4877
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1 Cited Publications
Referencia número: HY-129492
No. CAS: 2041073-22-5
Pureza:  99.78%
Target:  

DYRK GSK-3

Áreas de investigación:  

Metabolic Disease

GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells) .
1
Maltose monohydrate
Maltose monohydrate
0 Images
1 Cited Publications
Referencia número: HY-N2024A
No. CAS: 6363-53-7
Category:  

other families Polysaccharides Other Diseases Plants Endogenous metabolite Disease Research Fields Saccharides

Target:  

Endogenous Metabolite Glycosidase

Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders .
1
Rebaudioside D
Rebaudioside D
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1 Cited Publications
Referencia número: HY-N0468
No. CAS: 63279-13-0
Category:  

other families Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Food Research

Target:  

FXR Acetyl-CoA Carboxylase

Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .
1
Clemastanin B
Clemastanin B
0 Images
1 Cited Publications
Referencia número: HY-N6025
No. CAS: 112747-98-5
Category:  

Cruciferae Lignans Isatis tinctoria L. Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Influenza Virus

Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities .
1
Artesunate (Standard)
Artesunate (Standard)
0 Images
1 Cited Publications
Referencia número: HY-N0193R
No. CAS: 88495-63-0
Category:  

Terpenoids Sesquiterpenes Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae

Target:  

Reference Standards STAT Ferroptosis Parasite Virus Protease

Artesunate (Standard) is the analytical standard of Artesunate. This product is intended for research and analytical applications. Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).
Felezonexor
Felezonexor
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Referencia número: HY-108716
No. CAS: 1076235-04-5
Pureza:  98.84%
Synonyms: CBS9106; SL-801
Target:  

CRM1 Apoptosis

Áreas de investigación:  

Cancer

CBS9106 (SL-801) is a reversible oral CRM1 inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells .
Ac-H-FluNox
Ac-H-FluNox
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Referencia número: HY-D2869
No. CAS: 2897614-60-5
Ac-H-FluNox is an acetylated cell-compatible prodrug of H-FluNox (HY-D2339). Ac-H-FluNox undergoes intracellular hydrolysis of its acetyl group by esterases to generate H-FluNox, which then undergoes a deoxygenation reaction with labile heme to form a fluorescent product. Ac-H-FluNox detects fluctuations of labile heme in living cells, acute labile heme release upon nitric oxide stimulation, and accumulation of labile heme following inhibition of heme export proteins .
Cholesteryl acetate
Cholesteryl acetate
0 Images
Referencia número: HY-107823
No. CAS: 604-35-3
Pureza:  99.41%
Synonyms: Cholesterol 3-acetate; Cholesterin acetate; Cholesterol 3β-acetate
Category:  

Other Diseases Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

Cholesteryl acetate (Cholesterol 3-acetate) is a cholesterol ester that is exported from Saccharomyces cerevisiae via a Pry1-dependent mechanism. Cholesteryl acetate binds to the CAP superfamily protein Pry1 via interactions dependent on Pry1’s caveolin-binding motif .
ICA-105665
ICA-105665
0 Images
Referencia número: HY-125469
No. CAS: 2694728-63-5
Pureza:  99.85%
Synonyms: PF-04895162
Target:  

Potassium Channel

Áreas de investigación:  

Neurological Disease

ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 inhibits liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM). ICA-105665 can penetrate the blood-brain barrier and has antiseizure effects .
BPKDi
BPKDi
0 Images
Referencia número: HY-118052
No. CAS: 1201673-28-0
Pureza:  99.60%
Target:  

PKD HDAC

Áreas de investigación:  

Cardiovascular Disease

BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells .
Leptomycin A
Leptomycin A
0 Images
Referencia número: HY-N6795
No. CAS: 87081-36-5
Category:  

Infection Microorganisms Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics

Target:  

CRM1 HIV Antibiotic

Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .
Biotinylated leptomycin B
Biotinylated leptomycin B
0 Images
Referencia número: HY-164710
Synonyms: b-LMB
Target:  

CRM1

Áreas de investigación:  

Others

Biotinylated leptomycin B is a compound used to quantify nuclear export protein 1 (XPO1) occupancy and is used to study the interaction of SINE compounds with XPO1 and the response of cancer cells to related compounds.
KLA seq acetate
KLA seq acetate
0 Images
Referencia número: HY-P4084A
Target:  

Peptides

Áreas de investigación:  

Others

KLA seq acetate is a cell membrane-penetrating α-helical amphipathic model peptide. KLA seq acetate conjugates peptide nucleic acids (PNAs) for delivery to mammalian cells. KLA seq acetate covalently links targeted mRNA and fluorescein to form a delivery system that has low re-export and is less resistant to serum effects .
NITD-304
NITD-304
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Referencia número: HY-W064918
No. CAS: 1473450-60-0
Target:  

Bacterial

Áreas de investigación:  

Infection

NITD-304 is an orally active anti-tuberculosis agent. NITD-304 exerts inhibitory and bactericidal activities gainst Mycobacterium tuberculosis and multidrug-resistant Mycobacterium tuberculosis. NITD-304 inhibits mycobacterial cell wall biosynthesis and demonstrates synergistic or additive growth inhibitory activity with select antibacterial agents. NITD-304 shows low risk of cardiotoxicity and drug-drug interactions, with no inhibition of major cytochrome P-450 enzymes or hERG channel. NITD-304 can be used for the research of tuberculosis and multidrug-resistant tuberculosis .
Assay Types