1201673-28-0
1201673-28-0
Chemical Structure
BPKDi
- CAS No.: 1201673-28-0
- Formula:C21H28N6O
- Molecular Weight:380.49
IUPAC Name: 2'-(cyclohexylamino)-6-(piperazin-1-yl)-[2,4'-bipyridine]-4-carboxamide
InChIKey: XNWDRALEEPGBHB-UHFFFAOYSA-N
SMILES: O=C(N)C1=CC(C2=CC(NC3CCCCC3)=NC=C2)=NC(N4CCNCC4)=C1
Biological Activity: BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BPKDi | 99.74% | BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.68
HY-128142PKC/PKD-IN-1 -
Similarity Score 0.52
HY-182974DCAF1 binder 3 -
Similarity Score 0.49
HY-163885SSZ -
Similarity Score 0.48
HY-114043NCGC00092410 -
Similarity Score 0.48
HY-100235RGSK591 (Standard) -
Similarity Score 0.48
HY-101188INCB38579 -
Similarity Score 0.48
HY-100235AGSK591 hydrochloride -
Similarity Score 0.47
HY-156296CDK9-Cyclin T1 PPI-IN-1 -
Similarity Score 0.47
HY-126146PKC-iota inhibitor 1 -
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