PKC-iota inhibitor 1
Based on 2 publication(s) in Google Scholar
PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 2328094-11-5
- Formula: C21H22N6O
- Molecular Weight:374.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) PKC-iota inhibitor 1
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Biological Activity
IC50: 0.34 μM (PKC-iota)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | GI50 |
11.3 μM
Compound: 19
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Antiproliferative activity against human HuH7 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human HuH7 cells assessed as cell growth inhibition measured after 72 hrs by CellTiter-Glo luminescent assay
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[PMID: 30891133] |
PKC-iota inhibitor 1 (Compound 19) exhibits weak growth inhibitory effects on the human hepatocellular carcinoma cell line Huh-7, with a GI50 of 11.3 μM[1].
PKC-iota inhibitor 1 (10 μM; 15 min) inhibits PD 102807 (HY-107646)-induced AMPK phosphorylation, while having no effect on methacholine-induced p-AMPK in human airway smooth muscle cells[2].
Pharmacokinetic Properties in Vitro[1]
Sol (pH 7.4, μg/mL)
Caco-2 (A-B, 10-6 cm/s)
MLM/HLM (CL, μL/min/mg)
164
0.28
71/5.1