2328094-11-5
2328094-11-5
Chemical Structure
PKC-iota inhibitor 1
- CAS. Nr.: 2328094-11-5
- Formula:C21H22N6O
- Molecular Weight:374.44
IUPAC Name: 2-amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide
InChIKey: YDMJAALVMGFGRY-UHFFFAOYSA-N
SMILES: NC1=C(C(NC2=CC=NC=C2)=O)C=C(C3=CC=CC(N4CCNCC4)=C3)C=N1
Biological Activity: PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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PKC-iota inhibitor 1 | 99.60% | PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC50 value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer. | ||||||||||||||||||||
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References
- [1]. Kwiatkowski J, et al. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. [Content Brief]
- [2]. Tompkins E, et al. The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype. J Biol Chem. 2023 Oct;299(10):105209. [Content Brief]
- [3]. Miyake Y, et al. Upregulation of OASIS/CREB3L1 in podocytes contributes to the disturbance of kidney homeostasis. Commun Biol. 2022 Jul 22;5(1):734. [Content Brief]
Keywords
