1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Ingenol

Ingenol (Synonyms: (-)-Ingenol)

Cat. No.: HY-N0865 Purity: >99.0%
Handling Instructions

Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

For research use only. We do not sell to patients.

Ingenol Chemical Structure

Ingenol Chemical Structure

CAS No. : 30220-46-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

IC50 & Target[1]

PKC

30 μM (Ki)

In Vitro

Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication[1].

Clinical Trial
Molecular Weight

348.43

Formula

C₂₀H₂₈O₅

CAS No.

30220-46-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (287.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8700 mL 14.3501 mL 28.7002 mL
5 mM 0.5740 mL 2.8700 mL 5.7400 mL
10 mM 0.2870 mL 1.4350 mL 2.8700 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Ingenol(-)-IngenolPKCProtein kinase CInhibitorinhibitorinhibit

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Ingenol
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