2. Epigenetics TGF-beta/Smad
  3. PKC
  4. Ingenol

Ingenol  (Synonyms: (-)-Ingenol)

Cat. No.: HY-N0865 Purity: 99.51%
COA Handling Instructions

Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

For research use only. We do not sell to patients.

Ingenol Chemical Structure

Ingenol Chemical Structure

CAS No. : 30220-46-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 130 In-stock
Solution
10 mM * 1 mL in DMSO USD 130 In-stock
Solid
1 mg USD 56 In-stock
5 mg USD 119 In-stock
10 mg USD 158 In-stock
50 mg USD 594 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Ingenol:

Ingenol Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

IC50 & Target[1]

PKC

30 μM (Ki)

In Vitro

Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ingenol Related Antibodies
Clinical Trial
Molecular Weight

348.43

Appearance

Solid

Formula

C20H28O5
CAS No.
SMILES

O[C@@]([C@@H](C(CO)=C[C@@]1([H])[C@H](C2(C)C)[C@H]2C3)O)([C@H]4O)[C@]([C@@H]3C)(C=C4C)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (287.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8700 mL 14.3501 mL 28.7002 mL
5 mM 0.5740 mL 2.8700 mL 5.7400 mL
10 mM 0.2870 mL 1.4350 mL 2.8700 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.51%

COA (264 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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Ingenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Ingenol30220-46-3(-)-IngenolPKCProtein kinase CInhibitorinhibitorinhibit

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