2041073-22-5
2041073-22-5
Chemical Structure
GNF4877
- CAS No.: 2041073-22-5
- Formula:C25H27FN6O4
- Molecular Weight:494.52
IUPAC Name: (R)-1-(3-(3-amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid
InChIKey: UZIATSFXNVOVFE-OAHLLOKOSA-N
SMILES: O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O
Biological Activity: GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GNF4877 | 99.82% | GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||||||||||||||||||||
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