Senkirkin
Based on 1 Customer Validation
Senkirkin is a pyrrolizidine alkaloid derived from Tussilago farfara. Senkirkin induces chromosomal damage in lymphocytes and is metabolized by CYP3A4.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.79%
- No. CAS: 2318-18-5
- Fòrmula: C19H27NO6
- Peso molecular:365.42
-
Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A204 | IC50 |
221 μg/mL
Compound: 6
|
Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay
Cytotoxicity against human A204 cells after 24 hrs by soft agar colony forming assay
|
[PMID: 3210016] |
Senkirkin binds to human CYP3A4[1].
Senkirkin (100 μM; 10 min preincubation, 60 min incubation with NADPH) is metabolized by cDNA-expressed human CYP3A4 and human liver microsomes[1].
Senkirkin (50-1000 μM; 24 hours) exhibits weak mitosis-inhibitory activity, and reduces the mitotic index to 24.5% at the concentration of 1000 μM in in vitro stimulated human primary lymphocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 2318-18-5
-
Appearance Solid
-
Peso molecular 365.42
-
Fòrmula C19H27NO6
-
Color White to off-white
-
SMILES
O=C(/C(C[C@@H](C)[C@]1(O)C)=C\C)O[C@](C2=O)([H])CCN(C)C/C=C2/COC1=O
-
Synonyms
Senkirkine; Renardin
-
Structure Classification
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Pureza y Documentación
-
Ficha de datos (273 KB)
-
SDS (643 KB)
- English - EN (643 KB)
- Français - FR (643 KB)
- Deutsch - DE (643 KB)
- Norwegian - NO (643 KB)
- Español - ES (643 KB)
- Swedish - SV (643 KB)
- Italian - IT (643 KB)
- Portuguese - PT (643 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz