Trk-IN-6
Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants (IC50 = 0.2-0.7 nM).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2489327-43-5
- Fòrmula: C21H21F3N6O2
- Peso molecular:446.43
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
0.2 nM
Compound: 8
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Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKA assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKA assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
| BaF3 | IC50 |
0.2 nM
Compound: 8
|
Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKC assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKC assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
| BaF3 | IC50 |
0.2 nM
Compound: 8
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Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA F589L mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA F589L mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
| BaF3 | IC50 |
0.3 nM
Compound: 8
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Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKB assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BaF3 cells transfected with ETV6-wild type TRKB assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
| BaF3 | IC50 |
1.6 nM
Compound: 8
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Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA G595R mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against mouse BAF3 cells transfected with LMNA-TRKA G595R mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
| BaF3 | IC50 |
10.9 nM
Compound: 8
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Antiproliferative activity aganist mouse BAF3 cells transfected with LMNA-TRKA G667C mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity aganist mouse BAF3 cells transfected with LMNA-TRKA G667C mutant assessed as cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 34668694] |
Chemical Information
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No. CAS 2489327-43-5
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Peso molecular 446.43
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Fòrmula C21H21F3N6O2
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SMILES
FC1=CC=C(OCC(F)F)C([C@@H](C)NC2=NC3=C(C4=CN(CCO)N=C4)C=NN3C=C2)=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trk-IN-6 Related Classifications
HY-139891 Related Classifications
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