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Referencia número: HY-151446

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ZIKV-IN-3

ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC₅₀ value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).

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No. CAS: 947699-46-9
Fòrmula: C₃₉H₄₁NO₄
Peso molecular:587.75

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

ZIKV-IN-3 Chemical Structure

No. CAS: 947699-46-9

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target

IC50: 18.34 μM (MTase)^[1]

Ver todos los productos específicos de isoformas DNA Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>200 μM Compound: 5a	Cytotoxicity against human A549 cells incubated for 96 hrs Cytotoxicity against human A549 cells incubated for 96 hrs	[PMID: 36055002]
Huh-7	CC₅₀	>200 μM Compound: 5a	Cytotoxicity against human Huh-7 cells incubated for 96 hrs Cytotoxicity against human Huh-7 cells incubated for 96 hrs	[PMID: 36055002]
Vero	CC₅₀	>200 μM Compound: 5a	Cytotoxicity against african green monkey Vero cells incubated for 96 hrs Cytotoxicity against african green monkey Vero cells incubated for 96 hrs	[PMID: 36055002]

In Vitro

ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC₅₀ value of 0.76 μM and has anti-ZIKV effect with EC₅₀ values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively^[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC₅₀ value of 0.38 μM and inhibits ZIKV replication and infection^[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells^[1]. Vero, Huh7 and A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Vero, Huh7 and A549 cells
Concentration:

0.08, 0.4, 2, 10, and 50 μM
Incubation Time:

96 hours
Result:

Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC₅₀>200 μM to all three cell lines.

Western Blot Analysis^[1]

Cell Line:

Vero cells
Concentration:

0.08, 0.4, 2, 10, and 50 μM
Incubation Time:

48 hours
Result:

Inhibited the expression of ZIKV E protein in a dose-dependent manner.

Chemical Information

No. CAS 947699-46-9
Peso molecular 587.75
Fòrmula C₃₉H₄₁NO₄
SMILES

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[C@@]23C)=N/O)=C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- In Vitro
Chemical Information
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ZIKV-IN-3

Ver todos los productos específicos de isoformas DNA Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ZIKV-IN-3 Related Classifications

HY-151446 Related Classifications