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CHERP - calcium homeostasis endoplasmic reticulum protein Gene

Also Known as SRA1; DAN16; SCAF6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10523

About CHERP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,517,894-16,542,437 (from NCBI)

This gene has 7 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 13.3), spleen (RPKM 10.7) and 25 other tissues.

Summary

Enables transmembrane transporter binding activity. Involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Acts upstream of or within cellular calcium ion homeostasis and negative regulation of cell population proliferation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CHERP Products (1)

mRNA	Protein	Name
NM_006387.6	NP_006378.3	calcium homeostasis endoplasmic reticulum protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21454501	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	10794731	GOA
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10794731	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	12656674	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	12656674	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10794731	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12656674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHERP Protein Structure

Surp

CTD_bind

G-patch

0
200
400
600
800
916 a.a.

Protein Preferred Names	Protein Names
calcium homeostasis endoplasmic reticulum protein	ERPROT 213-21

CHERP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHERP	Q8IWX8	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	CHERP	Q8IWX8	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	CHERP	Q8IWX8	RBFOX2	Homo sapiens	O43251-10	Y2H Array	32296183
Intra	CHERP	Q8IWX8	RBFOX2	Homo sapiens	O43251-10	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	CHERP	Q8IWX8	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	TLE3	Homo sapiens	Q04726-4	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	TLE3	Homo sapiens	Q04726-4	Y2H Array	32296183
Intra	CHERP	Q8IWX8	FIGN	Homo sapiens	Q5HY92	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	FIGN	Homo sapiens	Q5HY92	Y2H Array	32296183
Intra	CHERP	Q8IWX8	FASTK	Homo sapiens	Q14296	Y2H Array	32296183
Intra	CHERP	Q8IWX8	FASTK	Homo sapiens	Q14296	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	DHX8	Homo sapiens	Q14562	Y2H	22365833
Intra	CHERP	Q8IWX8	SNRNP27	Homo sapiens	Q8WVK2	Y2H	22365833
Intra	CHERP	Q8IWX8	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	32296183
Intra	CHERP	Q8IWX8	SAXO1	Homo sapiens	Q8IYX7	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	32296183
Intra	CHERP	Q8IWX8	LUC7L	Homo sapiens	Q9NQ29	Anti Tag CoIP	22365833
Intra	CHERP	Q8IWX8	LUC7L	Homo sapiens	Q9NQ29	Y2H	22365833
Intra	CHERP	Q8IWX8	FRA10AC1	Homo sapiens	Q70Z53	Anti Tag CoIP	22365833
Intra	CHERP	Q8IWX8	FRA10AC1	Homo sapiens	Q70Z53	Y2H	22365833
Intra	CHERP	Q8IWX8	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	CHERP	Q8IWX8	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	CHERP	Q8IWX8	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CHERP	Q8IWX8	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	22365833
Intra	CHERP	Q8IWX8	SF1	Homo sapiens	Q15637	Pull Down	26420826
Intra	CHERP	Q8IWX8	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
Intra	CHERP	Q8IWX8	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	CHERP	Q8IWX8	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	CHERP	Q8IWX8	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	CHERP	Q8IWX8	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	CHERP	Q8IWX8	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 7	Spinocerebellar Ataxia Type 7 SCA7 Opca3 Opca Iii Olivopontocerebellar Atrophy Iii Opca With Retinal Degeneration Opca With Macular Degeneration And External Ophthalmoplegia Adca, Type Ii Autosomal Dominant Cerebellar Ataxia Type 2 Olivopontocerebellar Atrophy 3 Autosomal Dominant Cerebellar Ataxia, Type Ii Autosomal Dominant Cerebellar Ataxia Type Ii Adca2 Adcaii Ataxia With Pigmentary Retinopathy Cerebellar Syndrome-Pigmentary Maculopathy Syndrome Olivopontocerebellar Atrophy With Retinal Degeneration Spinocerebellar Ataxia-7 Ataxia, Spinocerebellar, Type 7
Primary Cerebellar Degeneration	Spinocerebellar Degenerations Cerebellar Degenerations, Primary Spinocerebellar Degeneration
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Oculopharyngeal Muscular Dystrophy	OPMD Muscular Dystrophy, Oculopharyngeal Dystrophy, Oculopharyngeal Muscular Oculopharyngeal Dystrophy Progressive Muscular Dystrophy, Oculopharyngeal Type Muscular Dystrophy Oculopharyngeal Dystrophy, Muscular, Oculopharyngeal
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Pancreatic Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Pancreas Adenosquamous Carcinoma Of The Pancreas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02622	CHERP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHERP	VGNC	VGNC:39210
Bos taurus	CHERP	VGNC	VGNC:27287
Rattus norvegicus	CHERP	RGD	RGD:1305279
Felis catus	CHERP	VGNC	VGNC:60852
Mus musculus	CHERP	MGD	MGI:106417
Macaca mulatta	CHERP	VGNC	VGNC:70960
Others	CHERP	NCBI