Dusp22 - dual specificity phosphatase 22 Gene

Also Known as JKAP; JSP1; MKPX; LMW-DSP2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105352

Summary

Enables protein tyrosine kinase binding activity and protein tyrosine Phosphatase activity. Acts upstream of or within several processes, including negative regulation of T cell mediated immunity; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm; leading edge of lamellipodium; and plasma membrane. Predicted to be part of filamentous actin. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and somite. Orthologous to human DUSP22 (dual specificity Phosphatase 22). [provided by Alliance of Genome Resources, Apr 2022]

Dusp22 Products (2)

mRNA Protein Name
NM_001037955.4 NP_001033044.1 dual specificity protein phosphatase 22 isoform a
NM_134068.4 NP_598829.1 dual specificity protein phosphatase 22 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12138158 MGI
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
24714587 MGI
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
24714587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
24714587 MGI
acts upstream of or within negative regulation of T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
24714587 MGI
acts upstream of or within negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24714587 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
12138158 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12138158 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12138158 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 22

  • low molecular weight dual specificity phosphatase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123846 MLS-0437605 Inhibitor 99.27% Unkown
HY-133095 BML-260 Activator 99.65% Unkown
HY-RS04061 DUSP22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp22 NCBI NCBI:56940