DUSP22 - dual specificity phosphatase 22 Gene

Also Known as VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56940

About DUSP22

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:292,487-351,355 (from NCBI)

This gene has 16 transcripts (splice variants), 244 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 10.7), spleen (RPKM 5.4) and 25 other tissues.

Summary

Enables non-membrane spanning protein tyrosine Phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]

DUSP22 Products (2)

mRNA	Protein	Name
NM_001286555.3	NP_001273484.1	dual specificity protein phosphatase 22 isoform a
NM_020185.6	NP_064570.1	dual specificity protein phosphatase 22 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables non-membrane spanning protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	20018849	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	24714587	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	24714587	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	38225265	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	20018849	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	38225265	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20018849	GOA
involved in negative regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	20018849	GOA
involved in negative regulation of non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	20018849	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16636663	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	20018849	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20018849	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	20018849	GOA
located in leading edge of lamellipodium	IDA IDA: Inferred from direct assay	20018849	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24714587	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP22 Protein Structure

DSPc

0
100
184 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 22	JNK-stimulating phosphatase 1

Related Diseases

Diseases	Alias
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Variola Major	Smallpox
Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood	Ebv-Positive T-Cell Lymphoproliferative Disorder Of Childhood Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood Systemic Ebv-Positive T-Cell Lymphoma Of Childhood Systemic Ebv+ T-Cell Lymphoma Of Childhood
Hepatosplenic T-Cell Lymphoma	Doid:0081049
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Mature T-Cell And Nk-Cell Lymphoma	Mature T-Cell And Natural Killer Cell Lymphoma Nk-T Cell Lymphoma
Duane Retraction Syndrome	Stilling-Turk-Duane Syndrome Duane'S Syndrome Duane Syndrome Isolated Duane Retraction Syndrome Co-Contractive Retraction Syndrome Duane Anomaly, Isolated Ocular Retraction Syndrome Drs Durs
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123846	MLS-0437605	Inhibitor	99.27%	Unkown
HY-133095	BML-260	Activator	99.65%	Unkown
HY-RS04061	DUSP22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP22	RGD	RGD:1307146
Mus musculus	DUSP22	MGD	MGI:1915926
Canis familiaris	DUSP22	VGNC	VGNC:40133
Macaca mulatta	DUSP22	VGNC	VGNC:71844
Bos taurus	DUSP22	VGNC	VGNC:28256
Others	DUSP22	NCBI