DUSP22 - dual specificity phosphatase 22 Gene

Homo sapiens

Also known as VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2

Gene ID: 56940 | Gene type: protein coding

About DUSP22

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:292,487-351,355 (from NCBI)

This gene has 16 transcripts (splice variants), 244 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 10.7), spleen (RPKM 5.4) and 25 other tissues.

Summary

Enables non-membrane spanning protein tyrosine Phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]

DUSP22 Products(2)

mRNA	Protein	Name
NM_001286555.3	NP_001273484.1	dual specificity protein phosphatase 22 isoform a
NM_020185.6	NP_064570.1	dual specificity protein phosphatase 22 isoform b

DUSP22 Protein Structure

DSPc

0
100
184 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 22

JNK-stimulating phosphatase 1

Related Diseases

Diseases

Alias

Breast Implant-Associated Anaplastic Large Cell Lymphoma

Variola Major

Smallpox

Systemic Epstein-Barr Virus Positive T-Cell Lymphoma Of Childhood

Ebv-Positive T-Cell Lymphoproliferative Disorder Of Childhood	Systemic Epstein-Barr Virus-Positive T-Cell Lymphoma Of Childhood
Systemic Ebv-Positive T-Cell Lymphoma Of Childhood	Systemic Ebv+ T-Cell Lymphoma Of Childhood

Hepatosplenic T-Cell Lymphoma

Doid:0081049

Angioimmunoblastic T-Cell Lymphoma

Immunoblastic Lymphadenopathy	Lymphogranulomatosis X
T-Cell Lymphoma, Aild Type	Aitl
Ailt	Angioimmunoblastic Lymphadenopathy
Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]	Angioimmunoblastic Lymphoma

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123846	MLS-0437605	Inhibitor	99.92%	Unkown
HY-RS04061	DUSP22 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DUSP22	RGD	RGD:1307146
Mus musculus	DUSP22	MGD	MGI:1915926
Canis familiaris	DUSP22	VGNC	VGNC:40133
Macaca mulatta	DUSP22	VGNC	VGNC:71844
Bos taurus	DUSP22	VGNC	VGNC:28256

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