Krt5 - keratin 5 Gene

Also Known as K5; CK5; Tfip8; Krt2-5; 3300001P10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110308

Summary

Predicted to enable scaffold protein binding activity. Located in keratin filament and plasma membrane. Is expressed in several structures, including alimentary system; epithelium; genitourinary system; integumental system; and sensory organ. Used to study epidermolysis bullosa simplex Dowling-Meara type. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5). [provided by Alliance of Genome Resources, Apr 2022]

Krt5 Products (1)

mRNA Protein Name
NM_027011.3 NP_081287.1 keratin, type II cytoskeletal 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11063033 MGI
Biological Process GO Annotation Evidence References Source
involved in intermediate filament polymerization IMP
IMP: Inferred from mutant phenotype
11408584 MGI
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19267394 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
19267394 MGI
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
11408584 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12657653 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
7679677 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21464233 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 5

  • 58 kDa cytokeratin

  • cytokeratin 5

  • keratin complex 2, basic, gene 5

  • tuftelin interacting protein 8

  • type-II keratin Kb5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07457 KRT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt5 NCBI NCBI:3852