PDCD10 - programmed cell death 10 Gene

Also Known as CCM3; TFAR15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11235

About PDCD10

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,683,298-167,734,892 (from NCBI)

This gene has 18 transcripts (splice variants), 279 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 13.1), lymph node (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes an evolutionarily conserved protein associated with cell Apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

PDCD10 Products (3)

mRNA	Protein	Name
NM_007217.4	NP_009148.2	programmed cell death protein 10
NM_145859.2	NP_665858.1	programmed cell death protein 10
NM_145860.2	NP_665859.1	programmed cell death protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20489202	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi reassembly	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in establishment of Golgi localization	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	22291017	GOA
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI IGI: Inferred from genetic interaction	22652780	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17360971	GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17360971	GOA
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	23541896	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17360971	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	22652780	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20332113	GOA
NOT involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20332113	GOA
NOT involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	20332113	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	22652780	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20332113	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22652780	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17360971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD10 Protein Structure

DUF1241

0
100
200
212 a.a.

Protein Preferred Names	Protein Names
programmed cell death protein 10	TF-1 cell apoptosis-related protein 15

PDCD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Array	31515488
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	q96ba2_human	Homo sapiens	Q96BA2	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	q96ba2_human	Homo sapiens	Q96BA2	Validated Y2H	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	FRYL	Homo sapiens	O94915-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	FRYL	Homo sapiens	O94915-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PROSER2	Homo sapiens	Q86WR7-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PROSER2	Homo sapiens	Q86WR7-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Confocal	17657516
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Pull Down	17657516
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	BLI	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	Pull Down	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	GMS	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	X-Ray Diffraction	23665169
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	X-Ray Diffraction	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	SPR	23665169
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	Anti Tag CoIP	23541896
Intra	PDCD10	Q9BUL8	PLEKHS1	Homo sapiens	Q5SXH7-1	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PLEKHS1	Homo sapiens	Q5SXH7-1	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	PTPN13	Homo sapiens	Q12923	Pull Down	17657516
Intra	PDCD10	Q9BUL8	PTPN13	Homo sapiens	Q12923	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	MST4	Homo sapiens	Q499L9	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	MST4	Homo sapiens	Q499L9	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Anti Tag CoIP	33961781
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H	21516116
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Pull Down	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	SPR	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Solution Sedimentation	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	X-Ray Diffraction	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Pull Down	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	GMS	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	33961781
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	FARSA	Homo sapiens	Q9Y285	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	BLI	23541896
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Pull Down	23541896
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71190	PDCD10 Protein, Human	Q9BUL8 (M1-Al212 )	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations 3	Cerebral Cavernous Malformation 3 CCM3 Cerebral Cavernous Malformations-3 Cavernous Angiomatous Malformations Cavernous Hemangioma Of The Brain Cerebral Capillary Malformations Cerebral Cavernoma Familial Cavernous Angioma Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Cerebral Cavernous Malformation, Familial	Familial Cerebral Cavernous Malformation Familial Cavernous Hemangioma Familial Cerebral Cavernous Angioma Familial Brain Cavernous Angioma Familial Cerebral Cavernoma Hereditary Brain Cavernous Angioma Hereditary Cerebral Cavernoma Hereditary Cerebral Cavernous Malformation
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Cerebral Cavernous Malformations 2	Cerebral Cavernous Malformation 2 CCM2 Cerebral Cavernous Malformations-2 Cavernous Angiomatous Malformations Cavernous Hemangioma Of The Brain Cerebral Capillary Malformations Cerebral Cavernoma Familial Cavernous Angioma Cerebral Cavernous Malformations, Type 2
Brain Angioma	Brain Hemangioma
Intracranial Cavernous Angioma	Intracranial Cavernoma Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma	Angioma Of Intracranial Structure Hemangioma Of Intracranial Structure Hemangioma Of Intracranial Structures
Cerebral Angioma	Hemangioma Of Cerebrum Cerebral Hemangioma
Venous Malformations, Multiple Cutaneous And Mucosal	VMCM Multiple Cutaneous And Mucosal Venous Malformations Mucocutaneous Venous Malformations Vmcm1 Cutaneous And Mucosal Venous Malformation Dominantly Inherited Venous Malformations
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Hemangioma Of Liver	Hepatic Hemangioma Angioma Of Liver Hepatic Angioma
Myopathy, Centronuclear, 4	CNM4 Centronuclear Myopathy 4 Congenital Myopathy With Internal Nuclei And Atypical Cores Centronuclear Myopathy Type 4 Myopathy, Centronuclear, Type 4
Intracranial Abscess	Abscess Of Brain Brain Empyema Cranial Abscess Intracerebral Abscess Cerebral Abscess Cerebral Embolic Abscess Cerebral Pyogenic Abscess Septic Brain Infection Temporosphenoidal Abscess Ventricular Empyema Intracranial Suppuration Intracranial Vein Sinus Abscess
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency	MCC2D Mcc2 Deficiency 3-Methylcrotonyl Coa Carboxylase 2 Deficiency 3-Methylcrotonylglycinuria Ii Methylcrotonylglycinuria, Type Ii 3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency 3-Methylcrotonylglycinuria Type Ii Mcgii Methylcrotonylglycinuria Type Ii
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10188	PDCD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19799	Pdcd10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26295	Pdcd10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDCD10	RGD	RGD:1359329
Felis catus	PDCD10	VGNC	VGNC:68743
Bos taurus	PDCD10	VGNC	VGNC:32658
Mus musculus	PDCD10	MGD	MGI:1928396
Macaca mulatta	PDCD10	VGNC	VGNC:75793
Canis familiaris	PDCD10	VGNC	VGNC:53465
Others	PDCD10	NCBI