MYSM1 - Myb like, SWIRM and MPN domains 1 Gene

Also Known as 2ADUB; BMFS4; 2A-DUB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114803

About MYSM1

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:58,654,743-58,700,062 (from NCBI)

This gene has 26 transcripts (splice variants), 207 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 8.9), lymph node (RPKM 7.4) and 25 other tissues.

Summary

Enables histone binding activity; peptidase activity; and transcription coactivator activity. Involved in several processes, including chromatin remodeling; monoubiquitinated histone H2A deubiquitination; and positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of protein-containing complex. Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]

MYSM1 Products (1)

mRNA Protein Name
NM_001085487.3 NP_001078956.1 deubiquitinase MYSM1

MYSM1 Protein Structure

Myb_DNA-binding

Myb_DNA-binding: Myb-like DNA-binding domain (120 - 162)

SWIRM

SWIRM: SWIRM domain (374 - 461)

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (576 - 679)

  • 0
  • 200
  • 400
  • 600
  • 828 a.a.
Protein Preferred Names Protein Names

deubiquitinase MYSM1

  • histone H2A deubiquitinase MYSM1

MYSM1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P80939 MYSM1 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Bone Marrow Failure Syndrome 4

  • BMFS4
Congenital Progressive Bone Marrow Failure-B-Cell Immunodeficiency-Skeletal Dysplasia Syndrome

  • Mysm1 Deficiency
Hepatic Venoocclusive Disease With Immunodeficiency

  • VODI

  • Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome

  • Hepatic Veno-Occlusive Disease With Immunodeficiency

  • Familial Veno-Occlusive Disease With Immunodeficiency

  • Veno-Occlusive Disease And Immunodeficiency Syndrome

  • Vodi Syndrome

  • Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome
Inflammatory Bowel Disease 1

  • Inflammatory Bowel Disease 1

  • IBD1

  • Crohn Disease-Associated Growth Failure

  • Crohn Disease

  • Regional Enteritis

  • Ulcerative Colitis

  • Crohn Disease-Associated Growth Failure, Susceptibility To

  • Inflammatory Bowel Disease 1, Crohn Disease

  • Bowel Disease, Inflammatory, Type 1
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08972 MYSM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21660 Mysm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28178 Mysm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MYSM1 RGD RGD:1311787
Macaca mulatta MYSM1 VGNC VGNC:75039
Canis familiaris MYSM1 VGNC VGNC:43590
Mus musculus MYSM1 MGD MGI:2444584
Felis catus MYSM1 VGNC VGNC:63698
Bos taurus MYSM1 VGNC VGNC:31847
Others MYSM1 NCBI