MYSM1 Antibody
(Synonyms: Myb-like; SWIRM and MPN domains 1; 2ADUB; 2A-DUB; RP4-592A1.1)MYSM1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MYSM1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:100 |
Product Details
MYSM1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MYSM1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 95 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 95 kDa
Entrez Gene: 114803 Human ; 320713 Mouse ; 298247 Rat
SwissProt: Q5VVJ2 Human ; Q69Z66 Mouse ;
OMIM: 618116 Human
Synthetic peptide corresponding to Human MYSM1.The exact sequence is proprietary to MCE.
Endogenous
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216). Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232)
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Induction:By DNA from viral infection and intracellular DNA -
Isoforms & Post-Translational Modification
Q5VVJ2 has 3 isomers: Q5VVJ2-1: 95032 Da (predicted); Q5VVJ2-2: 66421 Da (predicted); Q5VVJ2-3: 26716 Da (predicted).
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Subunit
Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones (PubMed:17707232). Interacts with NFIL3; this interaction is critical for their correct recruitment to the ID2 locus during natural killer cell maturation (PubMed:24062447)
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SwissProt ID
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Synonyms
Myb-like; SWIRM and MPN domains 1; 2ADUB; 2A-DUB; RP4-592A1.1
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