AGAP3 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Gene

Homo sapiens

Also known as CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3

Gene ID: 116988 | Gene type: protein coding

About AGAP3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,085,867-151,144,434 (from NCBI)

This gene has 26 transcripts (splice variants), 199 orthologues and 28 paralogues. Ubiquitous expression in brain (RPKM 17.1), lung (RPKM 9.1) and 25 other tissues.

Summary

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

AGAP3 Products(8)

mRNA	Protein	Name
NM_001042535.4	NP_001036000.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b
NM_001281300.2	NP_001268229.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform c
NM_001308304.2	NP_001295233.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform d
NM_001308305.2	NP_001295234.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform e
NM_001350102.2	NP_001337031.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform f
NM_001350103.2	NP_001337032.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform g
NM_001350104.2	NP_001337033.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform h
NM_031946.7	NP_114152.3	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

AGAP3 Protein Structure

Roc

ArfGap

Ank_2

0
200
400
600
800
911 a.a.

Protein Preferred Names

Protein Names

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

CRAM-associated GTPase

Related Diseases

Diseases

Alias

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00439	AGAP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AGAP3	MGD	MGI:2183446
Canis familiaris	AGAP3	VGNC	VGNC:51785
Felis catus	AGAP3	VGNC	VGNC:59675
Bos taurus	AGAP3	VGNC	VGNC:25721
Rattus norvegicus	AGAP3	RGD	RGD:1310751
Macaca mulatta	AGAP3	VGNC	VGNC:69621

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