AGAP3 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Gene

Also Known as CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116988

About AGAP3

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,085,867-151,144,434 (from NCBI)

This gene has 26 transcripts (splice variants), 199 orthologues and 28 paralogues. Ubiquitous expression in brain (RPKM 17.1), lung (RPKM 9.1) and 25 other tissues.

Summary

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA Receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

AGAP3 Products (8)

mRNA Protein Name
NM_001042535.4 NP_001036000.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b
NM_001281300.2 NP_001268229.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform c
NM_001308304.2 NP_001295233.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform d
NM_001308305.2 NP_001295234.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform e
NM_001350102.2 NP_001337031.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform f
NM_001350103.2 NP_001337032.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform g
NM_001350104.2 NP_001337033.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform h
NM_031946.7 NP_114152.3 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

AGAP3 Protein Structure

Roc

Roc: Ras of Complex, Roc, domain of DAPkinase (129 - 236)

PH

PH: PH domain (405 - 638)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (665 - 775)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (790 - 879)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 911 a.a.
Protein Preferred Names Protein Names

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

  • CRAM-associated GTPase

Related Diseases

Diseases Alias
Machado-Joseph Disease

  • SCA3

  • MJD

  • Spinocerebellar Ataxia 3

  • Azorean Disease

  • Spinocerebellar Ataxia Type 3

  • Spinocerebellar Atrophy

  • Azorean Neurologic Disease

  • Spinopontine Atrophy

  • Nigrospinodentatal Degeneration

  • Spinocerebellar Atrophy Iii

  • Spinocerebellar Atrophy Type 3

  • Azorean Ataxia

  • Azorean Disease Of The Nervous System

  • Machado Disease

  • Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

  • Disease, Machado-Joseph

  • Ataxia, Spinocerebellar
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00439 AGAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AGAP3 MGD MGI:2183446
Canis familiaris AGAP3 VGNC VGNC:51785
Felis catus AGAP3 VGNC VGNC:59675
Bos taurus AGAP3 VGNC VGNC:25721
Rattus norvegicus AGAP3 RGD RGD:1310751
Macaca mulatta AGAP3 VGNC VGNC:69621
Others AGAP3 NCBI