TANGO2 - transport and golgi organization 2 homolog Gene

Also Known as MECRCN; C22orf25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 128989

About TANGO2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,017,023-20,067,164 (from NCBI)

This gene has 26 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues.

Summary

This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

TANGO2 Products (34)

mRNA Protein Name
NM_001283106.3 NP_001270035.1 transport and Golgi organization protein 2 homolog isoform a
NM_001283116.3 NP_001270045.1 transport and Golgi organization protein 2 homolog isoform a
NM_001283129.3 NP_001270058.1 transport and Golgi organization protein 2 homolog isoform b
NM_001283148.3 NP_001270077.1 transport and Golgi organization protein 2 homolog isoform c
NM_001283154.3 NP_001270083.1 transport and Golgi organization protein 2 homolog isoform c
NM_001283179.3 NP_001270108.1 transport and Golgi organization protein 2 homolog isoform d
NM_001283186.3 NP_001270115.1 transport and Golgi organization protein 2 homolog isoform d
NM_001283199.3 NP_001270128.1 transport and Golgi organization protein 2 homolog isoform e
NM_001283215.3 NP_001270144.1 transport and Golgi organization protein 2 homolog isoform f
NM_001283235.3 NP_001270164.1 transport and Golgi organization protein 2 homolog isoform g
NM_001283248.3 NP_001270177.1 transport and Golgi organization protein 2 homolog isoform h
NM_001322141.2 NP_001309070.1 transport and Golgi organization protein 2 homolog isoform i
NM_001322142.2 NP_001309071.1 transport and Golgi organization protein 2 homolog isoform j
NM_001322143.2 NP_001309072.1 transport and Golgi organization protein 2 homolog isoform b
NM_001322144.2 NP_001309073.1 transport and Golgi organization protein 2 homolog isoform l
NM_001322145.2 NP_001309074.1 transport and Golgi organization protein 2 homolog isoform m
NM_001322146.2 NP_001309075.1 transport and Golgi organization protein 2 homolog isoform k
NM_001322147.2 NP_001309076.1 transport and Golgi organization protein 2 homolog isoform m
NM_001322148.2 NP_001309077.1 transport and Golgi organization protein 2 homolog isoform n
NM_001322149.2 NP_001309078.1 transport and Golgi organization protein 2 homolog isoform r
NM_001322150.2 NP_001309079.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322153.2 NP_001309082.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322155.2 NP_001309084.1 transport and Golgi organization protein 2 homolog isoform o
NM_001322160.2 NP_001309089.1 transport and Golgi organization protein 2 homolog isoform p
NM_001322163.2 NP_001309092.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322166.2 NP_001309095.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322167.2 NP_001309096.1 transport and Golgi organization protein 2 homolog isoform d
NM_001322169.2 NP_001309098.1 transport and Golgi organization protein 2 homolog isoform q
NM_001322171.2 NP_001309100.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322172.2 NP_001309101.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322173.2 NP_001309102.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322174.2 NP_001309103.1 transport and Golgi organization protein 2 homolog isoform g
NM_001322175.2 NP_001309104.1 transport and Golgi organization protein 2 homolog isoform g
NM_152906.7 NP_690870.3 transport and Golgi organization protein 2 homolog isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
26805781 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
31276219 GOA
located in cytosol IDA
IDA: Inferred from direct assay
32909282 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
32909282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transport and Golgi organization protein 2 homolog

TANGO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TANGO2 Q6ICL3 SH3GL2 Homo sapiens Q99962
Anti Tag CoIP
33961781
Intra
TANGO2 Q6ICL3 SH3GL2 Homo sapiens Q99962
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Metabolic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

  • Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

  • MECRCN

  • Rhabdomyolysis
Tango2-Related Metabolic Encephalopathy And Arrhythmias

  • Recurrent Metabolic Encephalomyopathic Crises-Rhabdomyolysis-Cardiac Arrhythmia-Intellectual Disability Syndrome

  • Tango2

  • Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration

  • Tango2 Related Disease

  • Tango2-Related Metabolic Encephalopathy-Arrhythmia Syndrome

  • Tango2-Related Disorder
Episodic Ataxia

  • Isaacs Syndrome

  • Neuromyotonia

  • Isaacs' Syndrome

  • Acquired Neuromyotonia

  • Continuous Muscle Fiber Activity Syndrome

  • Quantal Squander Syndrome

  • Isaacs-Mertens Syndrome

  • Ea Syndrome

  • Episodic Ataxia Syndrome

  • Isaac Syndrome

  • Isaac'S-Merten'S Syndrome

  • Isaac-Mertens Syndrome

  • Peripheral Nerve Hyperexcitability

  • Ea

  • Peripheral Nerve Hyperexcitability Syndrome

  • Ataxia, Episodic

  • Isaacs Neuromyotonia

  • Continuous Muscle Fibre Activity
Hereditary Episodic Ataxia
Pitt-Hopkins-Like Syndrome 2

  • PTHSL2

  • Mesh

  • D006985

  • Mesh

  • D008607
Treacher Collins Syndrome 3

  • TCS3

  • Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal Recessive

  • Mandibulofacial Dysostosis Treacher Collins Type Autosomal Recessive
Lissencephaly 6

  • Lis6
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis

  • ECTD14

  • Ectodermal Dysplasia 14

  • Ectn14
Leukodystrophy, Hypomyelinating, 11

  • Hypomyelinating Leukodystrophy 11

  • HLD11

  • 4h Leukodystrophy 3

  • Leukodystrophy, Hypomyelinating, Type 11
Chromosome 6q24-Q25 Deletion Syndrome

  • Chromosome 6q25-Q25 Deletion Syndrome

  • 6q25 Microdeletion Syndrome

  • Monosomy 6q25

  • Del(6)(Q25)
Alternating Hemiplegia Of Childhood

  • Alternating Hemiplegia

  • Ahc

  • Alternating Hemiplegia Syndrome

  • Hemiplegia, Alternating, Of Childhood

  • Hemiplegia, Crossed
Velocardiofacial Syndrome

  • Shprintzen Syndrome

  • VCFS

  • Chromosome 22q11.2 Deletion Syndrome

  • Vcf Syndrome

  • Shprintzen Vcf Syndrome

  • Vcf-Velocardiofacial Syndrome

  • Velo-Cardio-Facial Syndrome

  • Digeorge Syndrome

  • 22q11 Deletion Syndrome

  • Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14196 TANGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TANGO2 RGD RGD:1310348
Canis familiaris TANGO2 VGNC VGNC:52971
Felis catus TANGO2 VGNC VGNC:65950
Mus musculus TANGO2 MGD MGI:101825
Bos taurus TANGO2 VGNC VGNC:106964
Macaca mulatta TANGO2 VGNC VGNC:78209
Others TANGO2 NCBI