Kpna2 - karyopherin (importin) alpha 2 Gene

Also Known as Rch1; IPOA1; PTAC58; 2410044B12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16647

Summary

Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Kpna2 Products (1)

mRNA Protein Name
NM_010655.3 NP_034785.1 importin subunit alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
12695505 MGI
enables nuclear import signal receptor activity IDA
IDA: Inferred from direct assay
15689618 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10764582 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
IMP: Inferred from mutant phenotype
28189564 MGI
acts upstream of or within positive regulation of viral life cycle IMP
IMP: Inferred from mutant phenotype
28189564 MGI
involved in postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
15603742 MGI
involved in postsynapse to nucleus signaling pathway IMP
IMP: Inferred from mutant phenotype
15603742 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
15689618 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
27430620 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15603742 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15603742 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15603742 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
15603742 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

importin subunit alpha-1

  • RAG cohort protein 1

  • SRP1-alpha

  • importin alpha 1

  • importin alpha P1

  • importin subunit alpha-2

  • karyopherin subunit alpha-2

  • m-importin-alpha-P1

  • pendulin

  • pore targeting complex 58 kDa subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17914 Kpna2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07416 KPNA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24383 Kpna2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kpna2 NCBI NCBI:3838