KPNA2 - karyopherin subunit alpha 2 Gene

Also Known as QIP2; RCH1; IPOA1; PTAC58; SRP1alpha; SRP1-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3838

About KPNA2

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:68,035,735-68,046,854 (from NCBI)

This gene has 21 transcripts (splice variants), 131 orthologues and 6 paralogues. Broad expression in testis (RPKM 102.8), bone marrow (RPKM 35.5) and 20 other tissues.

Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic Amino acids or 2 such regions spaced about 10 Amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

KPNA2 Products (2)

mRNA	Protein	Name
NM_001320611.2	NP_001307540.1	importin subunit alpha-1
NM_002266.4	NP_002257.1	importin subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	32290222	GOA
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	17324944	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9168958	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NLS-bearing protein import into nucleus	IDA IDA: Inferred from direct assay	17324944	GOA
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin	IMP IMP: Inferred from mutant phenotype	28189564	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	32130408	GOA
acts upstream of or within positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	28189564	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	32290222	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NLS-dependent protein nuclear import complex	IPI IPI: Inferred from physical interaction	10353244	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	7604027	GOA
is active in nuclear membrane	IDA IDA: Inferred from direct assay	7635189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA2 Protein Structure

IBB

Arm

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
importin subunit alpha-1	RAG cohort protein 1

KPNA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KPNA2	P52292	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	25416956
Intra	KPNA2	P52292	PNMA5	Homo sapiens	Q96PV4	Y2H Array	25416956
Intra	KPNA2	P52292	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	KPNA2	P52292	NUTM1	Homo sapiens	Q86Y26	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	NUTM1	Homo sapiens	Q86Y26	Validated Y2H	25416956
Intra	KPNA2	P52292	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	KPNA2	P52292	MORF4L1	Homo sapiens	Q9UBU8-2	Y2H Prey Pooling	32296183
Intra	KPNA2	P52292	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Cross	KPNA2	P52292	E6	Human papillomavirus	P03126	SLC	22898364
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974-1	GMS	19668212
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974-1	SAXS	19668212
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974-1	Solution Sedimentation	19668212
Intra	KPNA2	P52292	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	KPNA2	P52292	NUP50	Homo sapiens	Q9UKX7	Anti Tag CoIP	33961781
Intra	KPNA2	P52292	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KPNA2	P52292	NUP50	Homo sapiens	Q9UKX7	Y2H Array	25416956
Intra	KPNA2	P52292	NUP50	Homo sapiens	Q9UKX7	Anti Tag CoIP	35271311
Intra	KPNA2	P52292	NUP50	Homo sapiens	Q9UKX7	Y2H Prey Pooling	25416956
Cross	KPNA2	P52292	ns6_sars2	SARS-CoV-2	P0DTC6	Anti Tag CoIP	32979938
Cross	KPNA2	P52292	a0a3g5biz0_sars	SARS coronavirus Urbani	A0A3G5BIZ0	IF	17596301
Cross	KPNA2	P52292	a0a3g5biz0_sars	SARS coronavirus Urbani	A0A3G5BIZ0	Anti Tag CoIP	17596301
Intra	KPNA2	P52292	IRF3	Homo sapiens	Q14653	Anti Tag CoIP	34950606
Intra	KPNA2	P52292	RECQL	Homo sapiens	P46063	Pull Down	9168958
Intra	KPNA2	P52292	RECQL	Homo sapiens	P46063	Y2H	9168958
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	33961781
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	28514442
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974	Pull Down	11024021
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	17596301
Intra	KPNA2	P52292	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	35271311
Intra	KPNA2	P52292	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	KPNA2	P52292	NUP62	Homo sapiens	P37198	Y2H Array	25416956
Intra	KPNA2	P52292	BRCA1	Homo sapiens	P38398	Y2H	9497340
Intra	KPNA2	P52292	S100A6	Homo sapiens	P06703	Pull Down	20965181
Intra	KPNA2	P52292	HNRNPC	Homo sapiens	P07910	Validated Y2H	25416956
Intra	KPNA2	P52292	HNRNPC	Homo sapiens	P07910	Y2H	21988832
Intra	KPNA2	P52292	HNRNPC	Homo sapiens	P07910	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	DCPS	Homo sapiens	Q96C86	Validated Y2H	32296183
Intra	KPNA2	P52292	NMNAT1	Homo sapiens	Q9HAN9	Y2H Array	31515488
Intra	KPNA2	P52292	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	25416956
Intra	KPNA2	P52292	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
Cross	KPNA2	P52292	lt_sv40	Simian virus 40	P03070	Pull Down	20701745
Intra	KPNA2	P52292	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Cross	KPNA2	P52292	L2	Human papillomavirus	P03107	Pull Down	15507604
Cross	KPNA2	P52292	L1	Human papillomavirus	P03101	Pull Down	15507604
Intra	KPNA2	P52292	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	KPNA2	P52292	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	KPNA2	P52292	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	25416956
Intra	KPNA2	P52292	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	KPNA2	P52292	TADA2A	Homo sapiens	O75478	Y2H Array	25416956
Intra	KPNA2	P52292	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
Intra	KPNA2	P52292	MLH1	Homo sapiens	P40692	Y2H Array	31515488
Intra	KPNA2	P52292	MLH1	Homo sapiens	P40692	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	MLH1	Homo sapiens	P40692	Y2H Array	29892012
Intra	KPNA2	P52292	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826
Intra	KPNA2	P52292	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	25416956
Intra	KPNA2	P52292	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	25416956
Intra	KPNA2	P52292	S100A2	Homo sapiens	P29034	Pull Down	20965181
Intra	KPNA2	P52292	INO80E	Homo sapiens	Q8NBZ0	Y2H Array	25416956
Intra	KPNA2	P52292	INO80E	Homo sapiens	Q8NBZ0	Y2H Prey Pooling	25416956
Intra	KPNA2	P52292	JUN	Homo sapiens	P05412	Pull Down	21988832
Intra	KPNA2	P52292	RNMT	Homo sapiens	O43148	Anti Tag CoIP	35271311
Cross	KPNA2	P52292	npm2.L	Crosspus laevis	Q6GQG6	Pull Down	20965181

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KPNA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70371	Importin alpha-1/KPNA2 Protein, Human (His)	P52292 (M1-F529)	≥ 90%, as determined by reducing SDS-PAGE.

KPNA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81670	KPNA2 Antibody (YA1415)	WB, FC	Human, Mouse, Rat
HY-P84380	KPNA2 Antibody (YA4077)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84380A	KPNA2 Antibody (YA4077)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Nijmegen Breakage Syndrome	Berlin Breakage Syndrome NBS Microcephaly, Normal Intelligence And Immunodeficiency Ataxia-Telangiectasia Variant Ataxia-Telangiectasia Variant V1 Seemanova Syndrome Ii Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome Seemanova Syndrome Type 2 At-V1 Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence Immunodeficiency, Microcephaly, And Chromosomal Instability Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome Microcephaly Immunodeficiency Lymphoreticuloma Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence Seemanova Syndrome 2 Ataxia-Telangiectasia Variant 1 Seemanova Syndrome At V1 Ataxia-Telangiectasia, Variant 1 Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome V-At Ataxia Telangiectasia Variant V1
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Ovarian Endodermal Sinus Tumor	Endodermal Sinus Tumor Of Ovary Ovarian Yolk Sac Tumor Endodermal Sinus Tumour Of Ovary Ovarian Endodermal Sinus Tumour Ovarian Yolk Sac Tumour
Ovarian Primitive Germ Cell Tumor
Ovarian Dysgenesis 2	Premature Ovarian Failure 4 ODG2 Ovarian Dysgenesis, Hypergonadotropic, X-Linked Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis X-Linked Hypergonadotropic Ovarian Dysgenesis POF4 Dysgenesis, Ovarian, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17914	Kpna2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07416	KPNA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24383	Kpna2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KPNA2	VGNC	VGNC:97476
Bos taurus	KPNA2	VGNC	VGNC:30701
Rattus norvegicus	KPNA2	RGD	RGD:621419
Mus musculus	KPNA2	MGD	MGI:103561
Others	KPNA2	NCBI