FBXO15 - F-box protein 15 Gene

Also Known as FBX15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201456

About FBXO15

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:74,073,368-74,147,834 (from NCBI)

This gene has 14 transcripts (splice variants), 239 orthologues and 1 paralogue. Biased expression in testis (RPKM 2.7), kidney (RPKM 0.4) and 3 other tissues.

Summary

Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXO15 Products (2)

mRNA Protein Name
NM_001142958.2 NP_001136430.1 F-box only protein 15 isoform 2
NM_152676.3 NP_689889.1 F-box only protein 15 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO15 Protein Structure

F-box-like

F-box-like: F-box-like (77 - 117)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

F-box only protein 15

FBXO15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
FBXO15 Q8NCQ5 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04796 FBXO15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXO15 RGD RGD:1310628
Bos taurus FBXO15 VGNC VGNC:28893
Macaca mulatta FBXO15 VGNC VGNC:72504
Mus musculus FBXO15 MGD MGI:1354755
Felis catus FBXO15 VGNC VGNC:62177
Canis familiaris FBXO15 VGNC VGNC:40763
Others FBXO15 NCBI