Nrros - negative regulator of reactive oxygen species Gene

Also Known as Lrcc33; Lrrc33; E430025L02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 224109

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface and endoplasmic reticulum. Is expressed in embryo and thymus primordium. Orthologous to human NRROS (negative regulator of Reactive Oxygen Species). [provided by Alliance of Genome Resources, Apr 2022]

Nrros Products (3)

mRNA Protein Name
NM_001347181.1 NP_001334110.1 transforming growth factor beta activator LRRC33 isoform 2 precursor
NM_001347182.1 NP_001334111.1 transforming growth factor beta activator LRRC33 isoform 3
NM_146069.5 NP_666181.3 transforming growth factor beta activator LRRC33 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24739962 MGI
enables receptor ligand inhibitor activity IDA
IDA: Inferred from direct assay
29909984 MGI
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
29909984 MGI
Biological Process GO Annotation Evidence References Source
involved in immune response IMP
IMP: Inferred from mutant phenotype
24739962 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24739962 MGI
NOT involved in innate immune response IDA
IDA: Inferred from direct assay
29909984 MGI
involved in microglia development IMP
IMP: Inferred from mutant phenotype
28459434 MGI
involved in sequestering of TGFbeta in extracellular matrix IDA
IDA: Inferred from direct assay
29909984 MGI
NOT involved in superoxide metabolic process IDA
IDA: Inferred from direct assay
29909984 MGI
involved in superoxide metabolic process IMP
IMP: Inferred from mutant phenotype
24739962 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
29909984 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
29909984 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
24739962 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transforming growth factor beta activator LRRC33

  • leucine rich repeat containing 33

  • leucine-rich repeat-containing protein 33

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09581 NRROS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19727 Nrros Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26223 Nrros Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrros NCBI NCBI:375387