NRROS - negative regulator of reactive oxygen species Gene

Also Known as GARPL1; LRRC33; SENEBAC; UNQ3030; ELLP3030

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 375387

About NRROS

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,639,694-196,662,004 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 8.2) and 22 other tissues.

Summary

Enables transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NRROS Products (1)

mRNA Protein Name
NM_198565.3 NP_940967.1 transforming growth factor beta activator LRRC33 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transforming growth factor beta binding IPI
IPI: Inferred from physical interaction
29909984 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
29909984 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRROS Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (134 - 156)

LRR_8

LRR_8: Leucine rich repeat (157 - 217)

LRR_8

LRR_8: Leucine rich repeat (330 - 388)

LRR_6

LRR_6: Leucine Rich repeat (426 - 439)

(463 - 478)

(536 - 552)

LRR_1

LRR_1: Leucine Rich Repeat (560 - 575)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta activator LRRC33

  • glycoprotein A repetitions predominant like 1

Recombinant NRROS Proteins

Cat. No. Product Name Accession Purity
HY-P72063 NRROS Protein, Human (sf9, His-Myc) Q86YC3 (W19-L650) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Seizures, Early-Onset, With Neurodegeneration And Brain Calcifications

  • Seizures, Early-Onset, With Neurodegeneration And Brain Calcification

  • SENEBAC
Immunodeficiency 46

  • Tfrc-Related Combined Immunodeficiency

  • IMD46

  • Cid Due To Tfrc Deficiency

  • Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome

  • Chromosome 3q29 Microdeletion Syndrome

  • 3q29 Microdeletion Syndrome

  • 3q Subtelomere Deletion Syndrome

  • 3q29 Recurrent Deletion

  • 3qter Deletion

  • 3q29 Deletion Syndrome

  • Monosomy 3q29

  • Microdeletion 3q29 Syndrome

  • Del(3)(Q29)

  • Monosomy 3qter

  • 3q29 Deletion

  • Del3q29
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09581 NRROS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19727 Nrros Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26223 Nrros Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NRROS VGNC VGNC:63883
Macaca mulatta NRROS VGNC VGNC:75456
Rattus norvegicus NRROS RGD RGD:1310771
Bos taurus NRROS VGNC VGNC:53592
Mus musculus NRROS MGD MGI:2445095
Others NRROS NCBI