Rnasel - ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) Gene

Also Known as E230029I04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24014

Summary

Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in cerebellum; embryo; hippocampus; retina inner nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate Cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Apr 2022]

Rnasel Products (1)

mRNA Protein Name
NM_011882.2 NP_036012.1 2-5A-dependent ribonuclease

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
22441668 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fat cell differentiation IGI
IGI: Inferred from genetic interaction
22441668 MGI
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22441668 MGI
acts upstream of or within positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
22441668 MGI
acts upstream of or within regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
22441668 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-5A-dependent ribonuclease

  • 2-5A-dependent RNAase

  • 2-5A-dependent RNase

  • RNase L

  • ribonuclease 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12029 RNASEL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnasel NCBI NCBI:6041