Atp2b2 - ATPase plasma membrane Ca2+ transporting 2 Gene

Rattus norvegicus

Also known as PMCA2

Gene ID: 24215 | Gene type: protein coding

About Atp2b2

Summary

Enables several functions, including ATP binding activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in brain development and neural retina development. Located in several cellular components, including apical plasma membrane; neuronal cell body membrane; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b2 Products(1)

mRNA	Protein	Name
NM_012508.8	NP_036640.1	plasma membrane calcium-transporting ATPase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	2837461	RGD
enables P-type calcium transporter activity	IDA IDA: Inferred from direct assay	2837461	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	16554037	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	19406213	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in neural retina development	IEP IEP: Inferred from expression pattern	16079002	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23622064	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16763047	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16554037	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	17183553	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17183553	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16554037	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	17596212	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	17183553	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	20678993	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	17183553	RGD
is active in presynaptic active zone membrane	EXP EXP: Inferred from Experiment	23622064	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23622064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plasma membrane calcium-transporting ATPase 2

ATPase, Ca++ transporting, plasma membrane 2	plasma membrane Ca++-ATPase
plasma membrane calcium ATPase	plasma membrane calcium pump

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01195	ATP2B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01197	ATP2B4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2b2	NCBI	NCBI:491

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