Atp2b2 - ATPase plasma membrane Ca2+ transporting 2 Gene

Also Known as PMCA2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24215

Summary

Enables several functions, including ATP binding activity; P-type calcium transporter activity; and PDZ domain binding activity. Involved in brain development and neural retina development. Located in several cellular components, including apical plasma membrane; neuronal cell body membrane; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b2 Products (1)

mRNA Protein Name
NM_012508.8 NP_036640.1 plasma membrane calcium-transporting ATPase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
2837461 RGD
enables P-type calcium transporter activity IDA
IDA: Inferred from direct assay
2837461 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
16554037 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
19406213 RGD
Biological Process GO Annotation Evidence References Source
involved in neural retina development IEP
IEP: Inferred from expression pattern
16079002 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
23622064 RGD
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16763047 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16554037 RGD
located in dendritic spine membrane IDA
IDA: Inferred from direct assay
17183553 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
23622064 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17183553 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16554037 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
17596212 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
17183553 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
20678993 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
17183553 RGD
is active in presynaptic active zone membrane EXP
EXP: Inferred from Experiment
23622064 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
23622064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma membrane calcium-transporting ATPase 2

  • ATPase, Ca++ transporting, plasma membrane 2

  • plasma membrane Ca++-ATPase

  • plasma membrane calcium ATPase

  • plasma membrane calcium pump

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01195 ATP2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01197 ATP2B4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2b2 NCBI NCBI:491