2. Gene
  3. Edn2 - endothelin 2 Gene

Edn2 - endothelin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Et2; VIC; ET-2; PPET2; RNEDN2S01

Gene ID: 24324 | Gene type: protein coding

About Edn2

Summary

Predicted to enable endothelin B receptor binding activity and hormone activity. Involved in several processes, including ovarian follicle rupture; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of hormone secretion. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human EDN2 (endothelin 2). [provided by Alliance of Genome Resources, Apr 2022]

Edn2 Products(1)

mRNA Protein Name
NM_012549.3 NP_036681.2 endothelin-2 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of hormone secretion IDA
IDA: Inferred from direct assay
1533364 RGD
involved in ovarian follicle rupture IDA
IDA: Inferred from direct assay
16410304 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
1533364 RGD
involved in positive regulation of hormone secretion IDA
IDA: Inferred from direct assay
1533364 RGD
involved in positive regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
12396026 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
1860178 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-2

Endothelin isopeptide 2

preproendothelin-2

vasoactive intestinal contractor

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04164 EDN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22152 Edn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edn2 NCBI NCBI:1907