Ptgis - prostaglandin I2 synthase Gene

Also Known as PGIS

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25527

Summary

Enables prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process and response to hypoxia. Located in extracellular space. Used to study brain ischemia and pulmonary hypertension. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Apr 2022]

Ptgis Products (1)

mRNA Protein Name
NM_031557.2 NP_113745.1 prostacyclin synthase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables prostaglandin-I synthase activity IDA
IDA: Inferred from direct assay
16094316 RGD
enables prostaglandin-I synthase activity IMP
IMP: Inferred from mutant phenotype
10359560 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
8888351 RGD
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
19344900 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
14629650 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10536678 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
17303142 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
10073980 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19344900 RGD
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
16094316 RGD
involved in prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
10359560 RGD
involved in response to alkaloid IEP
IEP: Inferred from expression pattern
18612919 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
11823676 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12062720 RGD
involved in response to hypoxia IMP
IMP: Inferred from mutant phenotype
16094316 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
12964126 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18612919 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostacyclin synthase

  • hydroperoxy icosatetraenoate dehydratase

  • prostaglandin I2 (prostacyclin) synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11389 PTGIS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgis NCBI NCBI:5740