Ptgis - prostaglandin I2 synthase Gene

Rattus norvegicus

Also known as PGIS

Gene ID: 25527 | Gene type: protein coding

About Ptgis

Summary

Enables prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process and response to hypoxia. Located in extracellular space. Used to study brain ischemia and pulmonary hypertension. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Apr 2022]

Ptgis Products(1)

mRNA	Protein	Name
NM_031557.2	NP_113745.1	prostacyclin synthase precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables prostaglandin-I synthase activity	IDA IDA: Inferred from direct assay	16094316	RGD
enables prostaglandin-I synthase activity	IMP IMP: Inferred from mutant phenotype	10359560	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	8888351	RGD
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	19344900	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	14629650	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10536678	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17303142	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	10073980	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19344900	RGD
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	16094316	RGD
involved in prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	10359560	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	18612919	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	11823676	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	12062720	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	16094316	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	12964126	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18612919	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prostacyclin synthase

hydroperoxy icosatetraenoate dehydratase

prostaglandin I2 (prostacyclin) synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11389	PTGIS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptgis	NCBI	NCBI:5740

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