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PTGIS - prostaglandin I2 synthase Gene

Also Known as CYP8; PGIS; PTGI; CYP8A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5740

About PTGIS

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,503,874-49,568,137 (from NCBI)

This gene has 2 transcripts (splice variants), 250 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in urinary bladder (RPKM 26.9), gall bladder (RPKM 23.0) and 16 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. However, this protein is considered a member of the Cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

PTGIS Products (1)

mRNA	Protein	Name
NM_000961.4	NP_000952.1	prostacyclin synthase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heme binding	IDA IDA: Inferred from direct assay	17020766	GOA
enables prostaglandin-I synthase activity	IDA IDA: Inferred from direct assay	15115769	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20122998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11551955	GOA
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	21296955	GOA
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	8185632	GOA
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	8185632	GOA
involved in icosanoid metabolic process	IDA IDA: Inferred from direct assay	15115769	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	20159982	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	20159982	GOA
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	20159982	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20122998	GOA
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	11551955	GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	11551955	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	15115769	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	20122998	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21035466	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21035466	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGIS Protein Structure

p450

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
prostacyclin synthase	cytochrome P450, family 8, subfamily A, polypeptide 1

PTGIS Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811185	PTGIS Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Childhood-Onset Schizophrenia	Childhood Schizophrenia Schizophrenia, Childhood
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11389	PTGIS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGIS	RGD	RGD:3438
Macaca mulatta	PTGIS	VGNC	VGNC:76587
Mus musculus	PTGIS	MGD	MGI:1097156
Canis familiaris	PTGIS	VGNC	VGNC:45149
Bos taurus	PTGIS	VGNC	VGNC:33509
Felis catus	PTGIS	VGNC	VGNC:69146
Others	PTGIS	NCBI