2. Gene
  3. SELENOW - Selenow selenoprotein W Gene

SELENOW - Selenow selenoprotein W Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as SelW; Sepw1

Gene ID: 25545 | Gene type: protein coding

About SELENOW

Summary

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 10. [provided by RefSeq, Aug 2017]

SELENOW Products(1)

mRNA Protein Name
NM_013027.3 NP_037159.4 selenoprotein W
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
19234057 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenoprotein W

selenoprotein W, 1

selenoprotein W, muscle 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12645 SELENOW Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SELENOW NCBI NCBI:6415