Slc1a1 - solute carrier family 1 member 1 Gene

Also Known as Eaac1; Eaat3; REAAC1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25550

Summary

Enables amino acid transmembrane transporter activity; glutamate binding activity; and identical protein binding activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including dendrite; perikaryon; and perisynaptic space. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a1 Products (1)

mRNA Protein Name
NM_013032.3 NP_037164.3 excitatory amino acid transporter 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
16128593 RGD
enables glutamate binding IDA
IDA: Inferred from direct assay
16128593 RGD
enables glutamate:sodium symporter activity IDA
IDA: Inferred from direct assay
16128593 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16128593 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16045453 RGD
Biological Process GO Annotation Evidence References Source
involved in L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
16128593 RGD
Cellular Component GO Annotation Evidence References Source
located in apical dendrite IDA
IDA: Inferred from direct assay
10701825 RGD
located in asymmetric synapse IDA
IDA: Inferred from direct assay
9542890 RGD
located in axon IDA
IDA: Inferred from direct assay
10701825 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
10701825 RGD
located in cell periphery IDA
IDA: Inferred from direct assay
9542890 RGD
located in cell surface IDA
IDA: Inferred from direct assay
18096700 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9334410 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
10701825 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
9542890 RGD
located in distal dendrite IDA
IDA: Inferred from direct assay
9542890 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18096700 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
26092725 RGD
located in glial cell projection IDA
IDA: Inferred from direct assay
9542890 RGD
located in membrane IDA
IDA: Inferred from direct assay
26133720 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9542890 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
9542890 RGD
located in perisynaptic space IDA
IDA: Inferred from direct assay
10701825 RGD
located in presynapse IDA
IDA: Inferred from direct assay
10701825 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
9542890 RGD
located in synaptic cleft IDA
IDA: Inferred from direct assay
10701825 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

excitatory amino acid transporter 3

  • Solute carrier family 1 A1 (brain glutamate transporter)

  • excitatory amino-acid carrier 1

  • sodium-dependent glutamate/aspartate transporter 3

  • solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-130125 SLC1A1/EAAT3-IN-1 Inhibitor 98.63% Unkown
HY-RS13050 SLC1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21933 Slc1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a1 NCBI NCBI:6505