Slc1a1 - solute carrier family 1 member 1 Gene

Rattus norvegicus

Also known as Eaac1; Eaat3; REAAC1

Gene ID: 25550 | Gene type: protein coding

About Slc1a1

Summary

Enables amino acid transmembrane transporter activity; glutamate binding activity; and identical protein binding activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including dendrite; perikaryon; and perisynaptic space. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a1 Products(1)

mRNA	Protein	Name
NM_013032.3	NP_037164.3	excitatory amino acid transporter 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	16128593	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	16128593	RGD
enables glutamate:sodium symporter activity	IDA IDA: Inferred from direct assay	16128593	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16128593	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16045453	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	16128593	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	10701825	RGD
located in asymmetric synapse	IDA IDA: Inferred from direct assay	9542890	RGD
located in axon	IDA IDA: Inferred from direct assay	10701825	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	10701825	RGD
located in cell periphery	IDA IDA: Inferred from direct assay	9542890	RGD
located in cell surface	IDA IDA: Inferred from direct assay	18096700	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9334410	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	10701825	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	9542890	RGD
located in distal dendrite	IDA IDA: Inferred from direct assay	9542890	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18096700	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	26092725	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	9542890	RGD
located in membrane	IDA IDA: Inferred from direct assay	26133720	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9542890	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9542890	RGD
located in perisynaptic space	IDA IDA: Inferred from direct assay	10701825	RGD
located in presynapse	IDA IDA: Inferred from direct assay	10701825	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	9542890	RGD
located in synaptic cleft	IDA IDA: Inferred from direct assay	10701825	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

excitatory amino acid transporter 3

Solute carrier family 1 A1 (brain glutamate transporter)	excitatory amino-acid carrier 1
sodium-dependent glutamate/aspartate transporter 3	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130125	SLC1A1/EAAT3-IN-1	Inhibitor	98.63%	Unkown
HY-RS13050	SLC1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21933	Slc1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a1	NCBI	NCBI:6505

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