Casp8ap2 - caspase 8 associated protein 2 Gene

Also Known as FLASH; D4Ertd659e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26885

Summary

Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process and extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Predicted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (Caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Casp8ap2 Products (2)

mRNA Protein Name
NM_001122978.2 NP_001116450.1 CASP8-associated protein 2
NM_011997.3 NP_036127.2 CASP8-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: Inferred from direct assay
10235259 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
10235259 MGI
enables protease binding IPI
IPI: Inferred from physical interaction
17245429 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10235259 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
10235259 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
10235259 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CASP8-associated protein 2

  • FLICE-associated huge protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01968 CASP8AP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Casp8ap2 NCBI NCBI:9994