Sh2d2a - SH2 domain containing 2A Gene

Also Known as Lad; Ribp; Tsad

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27371

Summary

Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within cell population proliferation. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in juvenile rheumatoid arthritis and multiple sclerosis. Orthologous to human SH2D2A (SH2 domain containing 2A). [provided by Alliance of Genome Resources, Apr 2022]

Sh2d2a Products (6)

mRNA Protein Name
NM_001025571.3 NP_001020742.1 SH2 domain-containing protein 2A isoform 2
NM_001411077.1 NP_001398006.1 SH2 domain-containing protein 2A isoform 3
NM_021309.4 NP_067284.1 SH2 domain-containing protein 2A isoform 1
NM_001025571.3 NP_001020742.1 SH2 domain-containing protein 2A isoform 2
NM_001411077.1 NP_001398006.1 SH2 domain-containing protein 2A isoform 3
NM_021309.4 NP_067284.1 SH2 domain-containing protein 2A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10553045 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
10587356 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2 domain-containing protein 2A

  • Lck-associated adapter protein

  • Rlk/Itk-binding protein

  • SH2 domain protein 2A

  • T cell-specific adapter protein

  • p56Lck-associated adapter protein

Sh2d2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh2d2a Q9QXK9 Lck Mus musculus P06240
CoIP
10553045
Intra
Sh2d2a Q9QXK9 Lck Mus musculus P06240
Y2H
10553045
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12823 SH2D2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2d2a NCBI NCBI:9047