Vkorc1 - vitamin K epoxide reductase complex, subunit 1 Gene

Mus musculus

Also known as D7Wsu86e

Gene ID: 27973 | Gene type: protein coding

About Vkorc1

Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]

Vkorc1 Products(1)

mRNA	Protein	Name
NM_178600.2	NP_848715.1	vitamin K epoxide reductase complex subunit 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA IDA: Inferred from direct assay	15879509	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	19492146	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	19492146	MGI
acts upstream of or within positive regulation of coagulation	IMP IMP: Inferred from mutant phenotype	15879509	MGI
acts upstream of or within vitamin K metabolic process	IDA IDA: Inferred from direct assay	15879509	MGI
involved in vitamin K metabolic process	IMP IMP: Inferred from mutant phenotype	19492146	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vitamin K epoxide reductase complex subunit 1

phylloquinone epoxide reductase	vitamin K 2,3-epoxide reductase complex subunit 1
vitamin K epoxide reductase subunit I	vitamin K1 2,3-epoxide reductase subunit 1
vitamin K1 epoxide reductase (warfarin-sensitive)

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15659	VKORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15660	VKORC1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vkorc1	NCBI	NCBI:79001

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