Homer2 - homer scaffold protein 2 Gene

Also Known as Vesl-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29547

Summary

Enables G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of interleukin-2 production. Predicted to act upstream of or within several processes, including behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; and chemical homeostasis within a tissue. Located in dendrite; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Homer2 Products (1)

mRNA Protein Name
NM_053309.2 NP_445761.1 homer protein homolog 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled glutamate receptor binding IPI
IPI: Inferred from physical interaction
15758184 RGD
enables glutamate receptor binding IPI
IPI: Inferred from physical interaction
9727012 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9727012 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15944415 RGD
enables protein domain specific binding IMP
IMP: Inferred from mutant phenotype
15944415 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9727012 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
15944415 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15944415 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17584991 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homer protein homolog 2

  • VASP/Ena-related gene up-regulated during seizure and LTP 2

  • cupidin

  • homer homolog 2

  • homer scaffolding protein 2

  • homer, neuronal immediate early gene, 2

  • homer-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06284 HOMER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Homer2 NCBI NCBI:9455