RHOD - ras homolog family member D Gene

Homo sapiens

Also known as Rho; ARHD; RHOM; RHOHP1

Gene ID: 29984 | Gene type: protein coding

About RHOD

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,056,847-67,072,017 (from NCBI)

This gene has 3 transcripts (splice variants), 100 orthologues and 22 paralogues. Ubiquitous expression in esophagus (RPKM 14.1), skin (RPKM 7.1) and 20 other tissues.

Summary

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin Cytoskeleton, and it may coordinate membrane transport with the function of the Cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

RHOD Products(2)

mRNA	Protein	Name
NM_001300886.2	NP_001287815.1	rho-related GTP-binding protein RhoD isoform 2
NM_014578.4	NP_055393.1	rho-related GTP-binding protein RhoD isoform 1

RHOD Protein Structure

Ras

0
100
210 a.a.

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoD

Rho-related protein HP1

Related Diseases

Diseases

Alias

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Tangier Disease

Analphalipoproteinemia	High Density Lipoprotein Deficiency, Tangier Type
TGD	High Density Lipoprotein Deficiency, Type 1
Hdldt1	Familial High Density Lipoprotein Deficiency
A-Alphalipoprotein Neuropathy	Alpha High Density Lipoprotein Deficiency Disease
Cholesterol Thesaurismosis	Familial High Density Lipoprotein Deficiency Disease
Hdl Lipoprotein Deficiency Disease	Tangier Disease Neuropathy
Familial Alpha-Lipoprotein Deficiency	Familial High-Density Lipoprotein Deficiency 1
Primary Hypoalphalipoproteinemia 1	Analphalipo-Proteinemia
Familial Hypoalphalipo-Proteinemia	Familial Hypoalphalipoproteinemia
Lipoprotein Deficiency Disease, Hdl, Familial	Tangier Hereditary Neuropathy
Atp-Binding Cassette Transporter A1 Deficiency	Hdld1
High Density Lipoprotein Deficiency 1	Tangier Disease, Variant
Hypoalphalipoproteinemia, Familial	Familial Hdl Deficiency

Toxic Megacolon

Megacolon, Toxic	Toxic Dilatation Of Colon
Toxic Functional Megacolon

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1005	Poloxamer 407 (F127)	Inhibitor	/	Unkown
HY-D0989	Rhod-2 AM		≥97.0%	Unkown
HY-136894	Rhod-5N		/	Unkown
HY-D1681	Rhod-590 AM Ester		/	Unkown
HY-RS11951	RHOD Human Pre-designed siRNA Set A		/	Unkown
HY-W127775	Demethyl Rhod-2 AM		/	Unkown
HY-W127781	RHOD 2 triammonium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RHOD	VGNC	VGNC:104322
Bos taurus	RHOD	VGNC	VGNC:33947
Mus musculus	RHOD	MGD	MGI:108446
Macaca mulatta	RHOD	VGNC	VGNC:81556
Canis familiaris	RHOD	VGNC	VGNC:45558
Rattus norvegicus	RHOD	RGD	RGD:1310985
Others	RHOD	NCBI

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