RHOD - ras homolog family member D Gene

Also Known as Rho; ARHD; RHOM; RHOHP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29984

About RHOD

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,056,847-67,072,017 (from NCBI)

This gene has 3 transcripts (splice variants), 100 orthologues and 22 paralogues. Ubiquitous expression in esophagus (RPKM 14.1), skin (RPKM 7.1) and 20 other tissues.

Summary

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin Cytoskeleton, and it may coordinate membrane transport with the function of the Cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

RHOD Products (2)

mRNA Protein Name
NM_001300886.2 NP_001287815.1 rho-related GTP-binding protein RhoD isoform 2
NM_014578.4 NP_055393.1 rho-related GTP-binding protein RhoD isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18218625 GOA
Biological Process GO Annotation Evidence References Source
involved in actin filament bundle assembly IMP
IMP: Inferred from mutant phenotype
23087206 GOA
involved in focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
23087206 GOA
involved in lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
23087206 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
23087206 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
23087206 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOD Protein Structure

Ras

Ras: Ras family (19 - 190)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoD

  • Rho-related protein HP1

RHOD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RHOD O00212 DAAM1 Homo sapiens Q9Y4D1
Pull Down
18218625
Intra
RHOD O00212 DAAM1 Homo sapiens Q9Y4D1
Anti Tag CoIP
33961781
Intra
RHOD O00212 DIAPH1 Homo sapiens O60610
Pull Down
18218625
Intra
RHOD O00212 DIAPH1 Homo sapiens O60610
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Clostridium Difficile Colitis

  • Pseudomembranous Colitis

  • Colitis Pseudomembranous

  • Enterocolitis, Pseudomembranous

  • Pseudomembranous Enterocolitis

  • Clostridium Difficile Infection
Wiskott-Aldrich Syndrome

  • WAS

  • Eczema-Thrombocytopenia-Immunodeficiency Syndrome

  • Immunodeficiency 2

  • Aldrich Syndrome

  • Imd2

  • Wiskott-Aldrich Syndrome 1

  • Was1

  • Wiskott Syndrome

  • Wiskott Aldrich Syndrome

  • Eczema Thrombocytopenia Immunodeficiency Syndrome

  • Imd 2
Tangier Disease

  • Analphalipoproteinemia

  • High Density Lipoprotein Deficiency, Tangier Type

  • TGD

  • High Density Lipoprotein Deficiency, Type 1

  • Hdldt1

  • Familial High Density Lipoprotein Deficiency

  • A-Alphalipoprotein Neuropathy

  • Alpha High Density Lipoprotein Deficiency Disease

  • Cholesterol Thesaurismosis

  • Familial High Density Lipoprotein Deficiency Disease

  • Hdl Lipoprotein Deficiency Disease

  • Tangier Disease Neuropathy

  • Familial Alpha-Lipoprotein Deficiency

  • Familial High-Density Lipoprotein Deficiency 1

  • Primary Hypoalphalipoproteinemia 1

  • Analphalipo-Proteinemia

  • Familial Hypoalphalipo-Proteinemia

  • Familial Hypoalphalipoproteinemia

  • Lipoprotein Deficiency Disease, Hdl, Familial

  • Tangier Hereditary Neuropathy

  • Atp-Binding Cassette Transporter A1 Deficiency

  • Hdld1

  • High Density Lipoprotein Deficiency 1

  • Tangier Disease, Variant

  • Hypoalphalipoproteinemia, Familial

  • Familial Hdl Deficiency
Toxic Megacolon

  • Megacolon, Toxic

  • Toxic Dilatation Of Colon

  • Toxic Functional Megacolon
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Vascular Disease

  • Vascular Diseases

  • Aneurysm

  • Spinal Cord Ischemia

  • Vascular Anomaly

  • Spinal Cord Vascular Diseases

  • Vascular Tissue Disease
Myopathy, Centronuclear, 2

  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0989 Rhod-2 AM ≥97.0% Unkown
HY-D1005 Poloxamer 407 (F127) Inhibitor / Unkown
HY-162543 18:1 Liss Rhod PE 99% Unkown
HY-DY1020 Rhod-2 AM (solution) / Unkown
HY-W127775 Demethyl Rhod-2 AM / Unkown
HY-104057 Rhod-FF AM / Unkown
HY-136784 Rhod-2 potassium / Unkown
HY-136894 Rhod-5N / Unkown
HY-D1681 Rhod-590 AM Ester / Unkown
HY-RS11951 RHOD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W127781 Rhod-2 triammonium / Unkown
HY-136784A Rhod-2 sodium / Unkown
HY-172627 Rhod-FF tripotassium / Unkown
HY-RS22304 Rhod Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28827 Rhod Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RHOD VGNC VGNC:104322
Bos taurus RHOD VGNC VGNC:33947
Mus musculus RHOD MGD MGI:108446
Macaca mulatta RHOD VGNC VGNC:81556
Canis familiaris RHOD VGNC VGNC:45558
Rattus norvegicus RHOD RGD RGD:1310985
Others RHOD NCBI