Ncoa1 - nuclear receptor coactivator 1 Gene

Rattus norvegicus

Also known as SRC-1

Gene ID: 313929 | Gene type: protein coding

About Ncoa1

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor binding activity. Involved in several processes, including animal organ development; estrous cycle; and mating behavior. Located in cytoplasm; neuron projection; and nucleus. Biomarker of hypothyroidism. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa1 Products(1)

mRNA	Protein	Name
NM_001395569.1	NP_001382498.1	nuclear receptor coactivator 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15166231	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	19460436	RGD
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	18566116	RGD
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15234273	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hormone stimulus	IMP IMP: Inferred from mutant phenotype	9808623	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	10803578	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	12551846	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	15862975	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	22085911	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	12551846	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	15946693	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	16189181	RGD
involved in male mating behavior	IMP IMP: Inferred from mutant phenotype	10861018	RGD
involved in positive regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	16769066	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17481888	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9564863	RGD
involved in response to estradiol	IMP IMP: Inferred from mutant phenotype	9808623	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9564863	RGD
involved in response to progesterone	IMP IMP: Inferred from mutant phenotype	9808623	RGD
involved in response to retinoic acid	IMP IMP: Inferred from mutant phenotype	9808623	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor coactivator 1

steroid receptor coactivator 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09089	NCOA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-146288	LXR agonist 2	Agonist	/	Unkown
HY-RS22672	Ncoa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncoa1	NCBI	NCBI:8648

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