Ncoa1 - nuclear receptor coactivator 1 Gene

Also Known as SRC-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313929

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor binding activity. Involved in several processes, including animal organ development; estrous cycle; and mating behavior. Located in cytoplasm; neuron projection; and nucleus. Biomarker of hypothyroidism. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa1 Products (1)

mRNA Protein Name
NM_001395569.1 NP_001382498.1 nuclear receptor coactivator 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15166231 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19460436 RGD
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
18566116 RGD
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
15234273 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15234273 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hormone stimulus IMP
IMP: Inferred from mutant phenotype
9808623 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
10803578 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
12551846 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
15862975 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
22085911 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
12551846 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
15946693 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
16189181 RGD
involved in male mating behavior IMP
IMP: Inferred from mutant phenotype
10861018 RGD
involved in positive regulation of female receptivity IMP
IMP: Inferred from mutant phenotype
16769066 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17481888 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9564863 RGD
involved in response to estradiol IMP
IMP: Inferred from mutant phenotype
9808623 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
9564863 RGD
involved in response to progesterone IMP
IMP: Inferred from mutant phenotype
9808623 RGD
involved in response to retinoic acid IMP
IMP: Inferred from mutant phenotype
9808623 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 1

  • steroid receptor coactivator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173033 MI-883 99.57% Unkown
HY-RS09089 NCOA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146288 LXR agonist 2 Agonist / Unkown
HY-RS22672 Ncoa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncoa1 NCBI NCBI:8648