Hif1an - hypoxia-inducible factor 1, alpha subunit inhibitor Gene

Also known as FIH; FIH1; 2310046M24Rik; A830014H24Rik

About Hif1an

Summary

Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Predicted to be involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and skeletal muscle. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor). [provided by Alliance of Genome Resources, Apr 2022]