Vwc2 - von Willebrand factor C domain containing 2 Gene

Also Known as G11; UNQ739; cradin; PSST739; A930041G11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 319922

Summary

Involved in negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane; extracellular space; and interstitial matrix. Part of AMPA glutamate receptor complex. Is expressed in alimentary system; blood vessel; and nervous system. Orthologous to human VWC2 (von Willebrand factor C domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Vwc2 Products (1)

mRNA Protein Name
NM_177033.3 NP_796007.1 brorin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
17400546 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
37591201 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
37591201 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
involved in positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17400546 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
located in basement membrane IDA
IDA: Inferred from direct assay
18757743 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
18757743 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
17400546 MGI
is active in extrinsic component of postsynaptic membrane IDA
IDA: Inferred from direct assay
37591201 MGI
is active in extrinsic component of postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
37591201 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
37591201 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
37591201 MGI
located in interstitial matrix IDA
IDA: Inferred from direct assay
18757743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

brorin

  • CR (chordin-like cysteine-rich) domain-containing adhesive protein

  • brain-specific chordin-like protein

  • von Willebrand factor C domain-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15732 VWC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16429 VWC2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20837 Vwc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21805 Vwc2l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27351 Vwc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28321 Vwc2l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vwc2 NCBI NCBI:375567