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VWC2 - von Willebrand factor C domain containing 2 Gene

Also Known as UNQ739; PSST739

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 375567

About VWC2

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:49,773,638-49,922,205 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 19 paralogues. Biased expression in heart (RPKM 2.5), ovary (RPKM 2.4) and 3 other tissues.

Summary

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.[provided by RefSeq, Oct 2009]

VWC2 Products (1)

mRNA	Protein	Name
NM_198570.5	NP_940972.2	brorin precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VWC2 Protein Structure

VWC

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
brorin	brain-specific chordin-like protein

VWC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VWC2	Q2TAL6	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	VWC2	Q2TAL6	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	KRTAP13-3	Homo sapiens	Q3SY46	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE3E	Homo sapiens	Q5T5B0	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE4A	Homo sapiens	Q5TA78	Y2H Array	32296183
Intra	VWC2	Q2TAL6	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	VWC2	Q2TAL6	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ZNF490	Homo sapiens	Q9ULM2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ZNF696	Homo sapiens	Q9H7X3	Anti Tag CoIP	33961781
Intra	VWC2	Q2TAL6	ZNF696	Homo sapiens	Q9H7X3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	SHFL	Homo sapiens	Q9NUL5-4	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE1A	Homo sapiens	Q5T7P2	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE1A	Homo sapiens	Q5T7P2	Y2H Array	32296183
Intra	VWC2	Q2TAL6	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	VWC2	Q2TAL6	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ZNF319	Homo sapiens	Q9P2F9	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	NTM	Homo sapiens	Q9P121-3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	POU4F2	Homo sapiens	Q12837	Y2H Array	32296183
Intra	VWC2	Q2TAL6	POU4F2	Homo sapiens	Q12837	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	CRY2	Homo sapiens	Q49AN0	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ABHD15	Homo sapiens	Q6UXT9	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	VWC2	Q2TAL6	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	LCE3D	Homo sapiens	Q9BYE3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	TRAPPC14	Homo sapiens	Q8WVR3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	TRAPPC14	Homo sapiens	Q8WVR3	Y2H Array	32296183
Intra	VWC2	Q2TAL6	TRAPPC14	Homo sapiens	Q8WVR3	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	OTX1	Homo sapiens	P32242	Y2H Array	32296183
Intra	VWC2	Q2TAL6	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	VWC2	Q2TAL6	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	FBXW5	Homo sapiens	Q969U6	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	VWC2	Q2TAL6	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	FUCA2	Homo sapiens	Q9BTY2	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	FUCA2	Homo sapiens	Q9BTY2	Y2H Prey Pooling	32296183
Intra	VWC2	Q2TAL6	FUCA2	Homo sapiens	Q9BTY2	Y2H Array	32296183
Intra	VWC2	Q2TAL6	LCE3A	Homo sapiens	Q5TA76	Validated Y2H	32296183
Intra	VWC2	Q2TAL6	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VWC2 Proteins

Cat. No.	상품명	Accession	Purity
HY-P77506	Brorin/VWC2 Protein, Human (HEK293, His)	Q2TAL6 (S28-M325)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tarsal-Carpal Coalition Syndrome	TCC Tarsal Carpal Coalition Syndrome Nog-Related-Symphalangism Spectrum Disorder
Craniodiaphyseal Dysplasia	CDD Schaefer Stein Oshman Syndrome Craniodiaphyseal Dysplasia, Dominant Dominantly Inherited Craniodiaphyseal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS15732	VWC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16429	VWC2L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20837	Vwc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21805	Vwc2l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27351	Vwc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28321	Vwc2l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VWC2	MGD	MGI:2442987
Canis familiaris	VWC2	VGNC	VGNC:52060
Rattus norvegicus	VWC2	RGD	RGD:1589624
Felis catus	VWC2	VGNC	VGNC:102729
Bos taurus	VWC2	VGNC	VGNC:36857
Macaca mulatta	VWC2	VGNC	VGNC:108452
Others	VWC2	NCBI