Scimp - SLP adaptor and CSK interacting membrane protein Gene

Also Known as A430084P05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 327957

Summary

Enables molecular adaptor activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of signal transduction; and Toll-like Receptor signaling pathway. Located in phagocytic vesicle. Part of receptor complex. Colocalizes with filopodium and ruffle. Orthologous to human SCIMP (SLP adaptor and CSK interacting membrane protein). [provided by Alliance of Genome Resources, Apr 2022]

Scimp Products (1)

mRNA	Protein	Name
NM_001045526.2	NP_001038991.1	SLP adapter and CSK-interacting membrane protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IMP IMP: Inferred from mutant phenotype	28098138	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21930792	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to molecule of fungal origin	IMP IMP: Inferred from mutant phenotype	27288407	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21930792	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	27288407	MGI
involved in positive regulation of dendritic cell cytokine production	IMP IMP: Inferred from mutant phenotype	27288407	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	28098138	MGI
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	27288407	MGI
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	28098138	MGI
involved in toll-like receptor TLR1:TLR2 signaling pathway	IMP IMP: Inferred from mutant phenotype	28098138	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with filopodium	IMP IMP: Inferred from mutant phenotype	28098138	MGI
located in phagocytic vesicle	IMP IMP: Inferred from mutant phenotype	27288407	MGI
part of receptor complex	IDA IDA: Inferred from direct assay	28098138	MGI
colocalizes with ruffle	IMP IMP: Inferred from mutant phenotype	28098138	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SLP adapter and CSK-interacting membrane protein	transmembrane protein C17orf87 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12511	SCIMP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scimp	NCBI	NCBI:388325