Abi2 - abl interactor 2 Gene

Also Known as AblBP3; ArgBP1; C130078H13; 8430425M24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 329165

Summary

Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin Cytoskeleton organization; and regulation of dendritic spine morphogenesis. Acts upstream of or within several processes, including camera-type eye development; dendrite development; and learning or memory. Located in adherens junction; dendrite; and glutamatergic synapse. Is active in dendritic spine and postsynaptic actin Cytoskeleton. Is expressed in several structures, including fronto-nasal process; future brain; intestine smooth muscle circular layer; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2022]

Abi2 Products (20)

mRNA Protein Name
NM_001198570.2 NP_001185499.1 abl interactor 2 isoform 1
NM_001198571.2 NP_001185500.1 abl interactor 2 isoform 2
NM_001404705.1 NP_001391634.1 abl interactor 2 isoform 4
NM_001404706.1 NP_001391635.1 abl interactor 2 isoform 5
NM_001404707.1 NP_001391636.1 abl interactor 2 isoform 6
NM_001404708.1 NP_001391637.1 abl interactor 2 isoform 7
NM_001404709.1 NP_001391638.1 abl interactor 2 isoform 8
NM_001404710.1 NP_001391639.1 abl interactor 2 isoform 9
NM_001404711.1 NP_001391640.1 abl interactor 2 isoform 10
NM_001404712.1 NP_001391641.1 abl interactor 2 isoform 11
NM_001404713.1 NP_001391642.1 abl interactor 2 isoform 12
NM_001404714.1 NP_001391643.1 abl interactor 2 isoform 13
NM_001404715.1 NP_001391644.1 abl interactor 2 isoform 14
NM_001404716.1 NP_001391645.1 abl interactor 2 isoform 15
NM_001404717.1 NP_001391646.1 abl interactor 2 isoform 16
NM_001404718.1 NP_001391647.1 abl interactor 2 isoform 17
NM_001404719.1 NP_001391648.1 abl interactor 2 isoform 18
NM_001404720.1 NP_001391649.1 abl interactor 2 isoform 19
NM_001404721.1 NP_001391650.1 abl interactor 2 isoform 20
NM_198127.3 NP_937760.1 abl interactor 2 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
15572692 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15572692 MGI
acts upstream of or within dendrite development IMP
IMP: Inferred from mutant phenotype
15572692 MGI
acts upstream of or within learning or memory IMP
IMP: Inferred from mutant phenotype
15572692 MGI
involved in lens fiber cell morphogenesis IMP
IMP: Inferred from mutant phenotype
15572692 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15572692 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
15572692 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
15572692 MGI
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
15572692 MGI
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15572692 MGI
involved in regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
15572692 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
15572692 MGI
located in dendrite IDA
IDA: Inferred from direct assay
15572692 MGI
is active in dendritic spine IDA
IDA: Inferred from direct assay
15572692 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15572692 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15572692 MGI
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
15572692 MGI
is active in postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
15572692 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

abl interactor 2

  • abelson interactor 2

  • abi-2

  • abl-binding protein 3

  • arg-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00099 ABI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abi2 NCBI NCBI:10152