Ksr2 - kinase suppressor of ras 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 333050

Summary

Enables MAP-kinase scaffold activity and mitogen-activated protein kinase kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within calcium-mediated signaling and positive regulation of MAPK cascade. Located in cytosol and plasma membrane. Orthologous to human KSR2 (kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Apr 2022]

Ksr2 Products (2)

mRNA Protein Name
NM_001312914.1 NP_001299843.1 kinase suppressor of Ras 2
NM_001312914.1 NP_001299843.1 kinase suppressor of Ras 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP-kinase scaffold activity IDA
IDA: Inferred from direct assay
19560418 MGI
enables mitogen-activated protein kinase kinase binding IDA
IDA: Inferred from direct assay
19560418 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19560418 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
19560418 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
19560418 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28180061 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19560418 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19560418 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinase suppressor of Ras 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100627 APS-2-79 Antagonist 99.38% Unkown
HY-100627A APS-2-79 hydrochloride Antagonist 98.42% Unkown
HY-RS02889 CNKSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07476 KSR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ksr2 NCBI NCBI:283455