Ppp1r1b - protein phosphatase 1, regulatory (inhibitor) subunit 1B Gene

Rattus norvegicus

Also known as Darpp32; Darpp-32

Gene ID: 360616 | Gene type: protein coding

About Ppp1r1b

Summary

Enables Dopamine Receptor binding activity. Involved in several processes, including memory; response to cocaine; and response to nicotine. Located in dendritic spine head; dendritic spine neck; and nucleus. Is active in glutamatergic synapse and postsynapse. Used to study mental depression; schizophrenia; status epilepticus; and withdrawal disorder. Biomarker of Huntington's disease. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein Phosphatase 1 regulatory inhibitor subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r1b Products(1)

mRNA	Protein	Name
NM_138521.1	NP_612530.1	protein phosphatase 1 regulatory subunit 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19465068	RGD
enables D2 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19465068	RGD
enables D3 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19465068	RGD
enables D4 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19465068	RGD
enables D5 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19465068	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12466426	RGD
involved in locomotory behavior	IDA IDA: Inferred from direct assay	22952905	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16687181	RGD
involved in response to cocaine	IDA IDA: Inferred from direct assay	26142455	RGD
involved in response to nicotine	IDA IDA: Inferred from direct assay	22952905	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine head	IDA IDA: Inferred from direct assay	24058659	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	24058659	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24058659	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	24058659	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 1B

dopamine- and cAMP-regulated neuronal phosphoprotein	dopamine- and cAMP-regulated phosphoprotein DARPP-32
neuronal phosphoprotein DARPP-32

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100384	NKL 22	Inhibitor	97.26%	Unkown
HY-RS10993	PPP1R1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r1b	NCBI	NCBI:84152

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