Ppp1r1b - protein phosphatase 1, regulatory (inhibitor) subunit 1B Gene

Also Known as Darpp32; Darpp-32

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360616

Summary

Enables Dopamine Receptor binding activity. Involved in several processes, including memory; response to cocaine; and response to nicotine. Located in dendritic spine head; dendritic spine neck; and nucleus. Is active in glutamatergic synapse and postsynapse. Used to study mental depression; schizophrenia; status epilepticus; and withdrawal disorder. Biomarker of Huntington's disease. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human PPP1R1B (protein Phosphatase 1 regulatory inhibitor subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r1b Products (1)

mRNA Protein Name
NM_138521.1 NP_612530.1 protein phosphatase 1 regulatory subunit 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D1 dopamine receptor binding IPI
IPI: Inferred from physical interaction
19465068 RGD
enables D2 dopamine receptor binding IPI
IPI: Inferred from physical interaction
19465068 RGD
enables D3 dopamine receptor binding IPI
IPI: Inferred from physical interaction
19465068 RGD
enables D4 dopamine receptor binding IPI
IPI: Inferred from physical interaction
19465068 RGD
enables D5 dopamine receptor binding IPI
IPI: Inferred from physical interaction
19465068 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12466426 RGD
involved in locomotory behavior IDA
IDA: Inferred from direct assay
22952905 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
16687181 RGD
involved in response to cocaine IDA
IDA: Inferred from direct assay
26142455 RGD
involved in response to nicotine IDA
IDA: Inferred from direct assay
22952905 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine head IDA
IDA: Inferred from direct assay
24058659 RGD
located in dendritic spine neck IDA
IDA: Inferred from direct assay
24058659 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24058659 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
24058659 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 1B

  • dopamine- and cAMP-regulated neuronal phosphoprotein

  • dopamine- and cAMP-regulated phosphoprotein DARPP-32

  • neuronal phosphoprotein DARPP-32

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-RS10993 PPP1R1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r1b NCBI NCBI:84152