Shisa6 - shisa family member 6 Gene

Also Known as Gm879; ckamp52

Species: Mus musculus

Gene Type: protein coding

Gene ID: 380702

Summary

Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in central nervous system. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Shisa6 Products (1)

mRNA	Protein	Name
NM_001034874.3	NP_001030046.1	protein shisa-6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	26931375	MGI
enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	26931375	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in excitatory chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26931375	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28196692	MGI
involved in postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	26931375	MGI
involved in postsynaptic neurotransmitter receptor diffusion trapping	IMP IMP: Inferred from mutant phenotype	26931375	MGI
involved in regulation of AMPA glutamate receptor clustering	IMP IMP: Inferred from mutant phenotype	26931375	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	26931375	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IMP IMP: Inferred from mutant phenotype	26931375	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28196692	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	22632720	MGI
located in asymmetric, glutamatergic, excitatory synapse	IDA IDA: Inferred from direct assay	26931375	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26931375	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	26931375	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26931375	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	26931375	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	26931375	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	26931375	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	26931375	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein shisa-6	cysteine-knot AMPAR-modulating protein 52 cystine-knot AMPAR modulating protein of 52 kDa protein shisa-6 homolog shisa homolog 6

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12869	SHISA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shisa6	NCBI	NCBI:388336