2. Gene
  3. Cdkl5 - cyclin-dependent kinase-like 5 Gene

Cdkl5 - cyclin-dependent kinase-like 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Stk9

Gene ID: 382253 | Gene type: protein coding

About Cdkl5

Summary

Predicted to enable ATP binding activity; protein kinase activity; and small GTPase binding activity. Acts upstream of or within protein localization to nucleus. Predicted to be located in several cellular components, including ciliary tip; dendritic growth cone; and microtubule organizing center. Predicted to be active in dendrite cytoplasm; glutamatergic synapse; and nucleus. Predicted to colocalize with ruffle membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study developmental and epileptic encephalopathy 2. Human ortholog(s) of this gene implicated in Rett syndrome; developmental and epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdkl5 Products(1)

mRNA Protein Name
NM_001024624.2 NP_001019795.1 cyclin-dependent kinase-like 5
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
27466189 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase-like 5

serine/threonine kinase 9

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-172198 GSK3-IN-10 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkl5 NCBI NCBI:6792