Slitrk3 - SLIT and NTRK-like family, member 3 Gene

Mus musculus

Also known as ST3

Gene ID: 386750 | Gene type: protein coding

About Slitrk3

Summary

Involved in regulation of presynapse assembly. Acts upstream of or within several processes, including GABAergic synaptic transmission; positive regulation of synapse assembly; and synapse organization. Located in GABA-ergic synapse and cell surface. Is integral component of postsynaptic membrane. Is expressed in alimentary system; bladder; central nervous system; neural retina; and peripheral nervous system. Orthologous to human SLITRK3 (SLIT and NTRK like family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slitrk3 Products(2)

mRNA	Protein	Name
NM_001357851.1	NP_001344780.1	SLIT and NTRK-like protein 3 precursor
NM_198864.3	NP_942564.2	SLIT and NTRK-like protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29107521	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	14550773	MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within gephyrin clustering involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	29107521	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IDA IDA: Inferred from direct assay	29107521	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within neurotransmitter-gated ion channel clustering	IMP IMP: Inferred from mutant phenotype	29107521	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
acts upstream of or within postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	29107521	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	22286174	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	22286174	MGI
acts upstream of or within synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	29107521	MGI
acts upstream of or within synaptic transmission, GABAergic	IGI IGI: Inferred from genetic interaction	29107521	MGI
acts upstream of or within synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	29107521	MGI
acts upstream of or within terminal button organization	IMP IMP: Inferred from mutant phenotype	29107521	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	22286174	MGI
located in GABA-ergic synapse	IDA IDA: Inferred from direct assay	29107521	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	22286174	MGI
located in cell surface	IDA IDA: Inferred from direct assay	29107521	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	22286174	MGI
is active in postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	22286174	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SLIT and NTRK-like protein 3

slit and trk like gene 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13375	SLITRK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slitrk3	NCBI	NCBI:22865

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