SLITRK3 - SLIT and NTRK like family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22865

About SLITRK3

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:165,186,720-165,197,109 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 25 paralogues. Biased expression in brain (RPKM 6.5), esophagus (RPKM 2.6) and 6 other tissues.

Summary

This gene encodes a member of the Slitrk family of structurally related transmembrane proteins that are involved in controlling neurite outgrowth. The encoded protein contains two leucine-rich repeat (LRR) domains and a C-terminal domain that is partially similar to Trk neurotrophin receptor protein. Enhanced expression of this gene was found in tissue from several different types of tumors. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Jan 2016]

SLITRK3 Products (3)

mRNA	Protein	Name
NM_001318810.2	NP_001305739.1	SLIT and NTRK-like protein 3 precursor
NM_001318811.2	NP_001305740.1	SLIT and NTRK-like protein 3 precursor
NM_014926.4	NP_055741.2	SLIT and NTRK-like protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	27565350	GOA
is active in postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	27565350	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK3 Protein Structure

LRR_8

LRR_1

LRR_8

0
200
400
600
800
977 a.a.

Protein Preferred Names	Protein Names
SLIT and NTRK-like protein 3	slit and trk like gene 3

SLITRK3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLITRK3	O94933	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SLITRK3	O94933	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SLITRK3	O94933	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 48	Combined Immunodeficiency Due To Zap70 Deficiency IMD48 Selective T-Cell Defect Stcd Zeta-Associated-Protein 70 Deficiency Severe Combined Immunodeficiency, Atypical Immunodeficiency, Type 48 Zap70 Deficiency
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13375	SLITRK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLITRK3	VGNC	VGNC:77761
Felis catus	SLITRK3	VGNC	VGNC:82369
Bos taurus	SLITRK3	VGNC	VGNC:34964
Canis familiaris	SLITRK3	VGNC	VGNC:46508
Rattus norvegicus	SLITRK3	RGD	RGD:1310506
Mus musculus	SLITRK3	MGD	MGI:2679447
Others	SLITRK3	NCBI