Elavl4 - ELAV like RNA binding protein 4 Gene

Also Known as HuD

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 432358

Summary

Enables mRNA 3'-UTR binding activity and translation regulator activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of dendrite development; and posttranscriptional regulation of gene expression. Located in several cellular components, including growth cone; neuronal cell body; and polysomal ribosome. Is active in glutamatergic synapse. Biomarker of hypothyroidism; learning disability; sciatic neuropathy; and status epilepticus. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Elavl4 Products (1)

mRNA	Protein	Name
NM_001077651.2	NP_001071119.2	ELAV-like protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	22736542	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	10436048	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21389246	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in associative learning	IEP IEP: Inferred from expression pattern	15519747	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	9514914	RGD
involved in nervous system development	IEP IEP: Inferred from expression pattern	9729424	RGD
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	9514914	RGD
involved in positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	22736542	RGD
involved in regeneration	IEP IEP: Inferred from expression pattern	12957493	RGD
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	22736542	RGD
involved in regulation of translation at postsynapse	IDA IDA: Inferred from direct assay	25692578	RGD
involved in regulation of translation at postsynapse	IMP IMP: Inferred from mutant phenotype	25692578	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19014379	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	23711134	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	15519747	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	15519747	RGD
located in dendrite	IDA IDA: Inferred from direct assay	14745023	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25692578	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25692578	RGD
located in growth cone	IDA IDA: Inferred from direct assay	15389607	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12859688	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	15389607	RGD
located in ribosome	IDA IDA: Inferred from direct assay	15519747	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ELAV-like protein 4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) ELAV like neuron-specific RNA binding protein 4 hu-antigen D paraneoplastic encephalomyelitis antigen HuD

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04297	ELAVL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18861	Elavl4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25353	Elavl4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Elavl4	NCBI	NCBI:1996