ELAVL4 - ELAV like RNA binding protein 4 Gene

Also Known as HUD; PNEM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1996

About ELAVL4

Cytogenetic location: 1p33-p32.3 Genomic coordinates (GRCh38): 1:50,048,055-50,203,772 (from NCBI)

This gene has 19 transcripts (splice variants), 207 orthologues and 24 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues.

Summary

Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of polysomal ribosome. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

ELAVL4 Products (15)

mRNA	Protein	Name
NM_001144774.3	NP_001138246.1	ELAV-like protein 4 isoform 2
NM_001144775.3	NP_001138247.2	ELAV-like protein 4 isoform 3
NM_001144776.3	NP_001138248.1	ELAV-like protein 4 isoform 4
NM_001144777.3	NP_001138249.1	ELAV-like protein 4 isoform 5
NM_001294348.2	NP_001281277.1	ELAV-like protein 4 isoform 6
NM_001324208.2	NP_001311137.1	ELAV-like protein 4 isoform 7
NM_001324209.2	NP_001311138.1	ELAV-like protein 4 isoform 8
NM_001324212.2	NP_001311141.1	ELAV-like protein 4 isoform 13
NM_001324213.2	NP_001311142.1	ELAV-like protein 4 isoform 9
NM_001324214.2	NP_001311143.1	ELAV-like protein 4 isoform 13
NM_001324215.2	NP_001311144.1	ELAV-like protein 4 isoform 10
NM_001324216.1	NP_001311145.1	ELAV-like protein 4 isoform 11
NM_001324217.2	NP_001311146.1	ELAV-like protein 4 isoform 12
NM_001410787.1	NP_001397716.1	ELAV-like protein 4 isoform 14
NM_021952.5	NP_068771.2	ELAV-like protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	10710437	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	12468554	GOA
enables poly(A) binding	IDA IDA: Inferred from direct assay	12034726	GOA
enables pre-mRNA intronic pyrimidine-rich binding	IDA IDA: Inferred from direct assay	17035636	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	12034726	GOA
involved in RNA processing	IDA IDA: Inferred from direct assay	17035636	GOA
involved in positive regulation of 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	18218628	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELAVL4 Protein Structure

RRM_1

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
ELAV-like protein 4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

Recombinant ELAVL4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72180	ELAVL4 Protein, Human (His-SUMO, Myc)	P26378-1 (M1-S380)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Lambert-Eaton Myasthenic Syndrome	Lambert-Eaton Syndrome Eaton-Lambert Syndrome Lems Lambert Eaton Myasthenic Syndrome Eaton Lambert Syndrome Lambert Eaton Syndrome Myasthenic Syndrome Of Lambert-Eaton Myasthenic-Myopathic Syndrome Of Lambert-Eaton Lems - [Lambert-Eaton Myasthenic Syndrome]
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Hallucinogen Abuse
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Hyperinsulinemic Hypoglycemia, Familial, 4	Hyperinsulinism Due To Glutamodehydrogenase Deficiency HHF4 Familial Hyperinsulinemic Hypoglycemia 4 Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Hyperinsulinism Due To Schad Deficiency Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Congenital Hyperinsulinism Schad Deficiency Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Myotonic Disease	Myotonic Disorders Myotonic Syndrome Symptomatic Myotonia
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04297	ELAVL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18861	Elavl4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25353	Elavl4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ELAVL4	VGNC	VGNC:61804
Rattus norvegicus	ELAVL4	RGD	RGD:1560027
Mus musculus	ELAVL4	MGD	MGI:107427
Macaca mulatta	ELAVL4	VGNC	VGNC:72203
Canis familiaris	ELAVL4	VGNC	VGNC:54201
Bos taurus	ELAVL4	VGNC	VGNC:52769
Others	ELAVL4	NCBI