Ldlrap1 - low density lipoprotein receptor adaptor protein 1 Gene

Rattus norvegicus

Also known as RGD1563417

Gene ID: 500564 | Gene type: protein coding

About Ldlrap1

Summary

Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and amyloid-beta binding activity. Predicted to be involved in several processes, including low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle clearance; and receptor-mediated endocytosis. Predicted to act upstream of or within Cholesterol homeostasis. Located in axon. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ldlrap1 Products(1)

mRNA	Protein	Name
NM_001109271.1	NP_001102741.1	low density lipoprotein receptor adapter protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14528014	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17727637	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low density lipoprotein receptor adapter protein 1

autosomal recessive hypercholesterolemia protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181997	LDLRAP1-IN-1	Inhibitor	/	Unkown
HY-RS07580	LDLRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldlrap1	NCBI	NCBI:26119

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